Table 2.

Univariable and multivariable analysis

VariableUnivariableMultivariable
RR95% CIPRR95% CIP
Factors predicting TTP using the conventional Mayo risk stratification system     
 Bone marrow plasma cells (≥10%) 0.3 0.1-5.1 .31  NA  
 Serum M-spike (≥3 g/dL) 2.0 1.3-2.9 .002 2.2 1.3-3.5 .003 
 sFLC ratio (≥8) 2.2 1.5-3.4 .0001 2.3 1.5-3.6 .0002 
 Elevated PCPI 2.0 1.3-3.0 .001 2.5 1.6-3.9 <.0001 
 Immunoparesis 1.6 1.0-2.5 .04 1.2 0.8-2.1 .39 
Factors predicting TTP using the proposed new Mayo risk stratification system       
 Bone marrow plasma cells (>20%) 2.7 1.8-4.1 <.0001 2.2 1.4-3.5 <0.0008 
 Serum M-spike (>2 g/dL) 2.2 1.5-3.2 <.0001 1.9 1.2-3.0 0.007 
 sFLC ratio (>20) 2.7 1.8-4.1 <.0001 2.7 1.7-4.2 0.22 
 Elevated PCPI 2.0 1.3-3.0 .001 2.3 1.4-3.5 0.0007 
 Immunoparesis 1.6 1.0-2.5 .04 1.0 0.6-1.7 0.97 
VariableUnivariableMultivariable
RR95% CIPRR95% CIP
Factors predicting TTP using the conventional Mayo risk stratification system     
 Bone marrow plasma cells (≥10%) 0.3 0.1-5.1 .31  NA  
 Serum M-spike (≥3 g/dL) 2.0 1.3-2.9 .002 2.2 1.3-3.5 .003 
 sFLC ratio (≥8) 2.2 1.5-3.4 .0001 2.3 1.5-3.6 .0002 
 Elevated PCPI 2.0 1.3-3.0 .001 2.5 1.6-3.9 <.0001 
 Immunoparesis 1.6 1.0-2.5 .04 1.2 0.8-2.1 .39 
Factors predicting TTP using the proposed new Mayo risk stratification system       
 Bone marrow plasma cells (>20%) 2.7 1.8-4.1 <.0001 2.2 1.4-3.5 <0.0008 
 Serum M-spike (>2 g/dL) 2.2 1.5-3.2 <.0001 1.9 1.2-3.0 0.007 
 sFLC ratio (>20) 2.7 1.8-4.1 <.0001 2.7 1.7-4.2 0.22 
 Elevated PCPI 2.0 1.3-3.0 .001 2.3 1.4-3.5 0.0007 
 Immunoparesis 1.6 1.0-2.5 .04 1.0 0.6-1.7 0.97 

RR, relative risk; CI, confidence interval.

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