Assessment of the prognostic role of onset of response (based on serum IgM concentration and coded as a time-dependent covariate) for survival after first-line treatment
| Response criteria (% SMIC reduction) . | Response status . | Median (IQR) time to response, mo . | Number at risk . | Number of deaths . | HR (95% CI) . | P . |
|---|---|---|---|---|---|---|
| 115 | 69 | |||||
| >25 | ||||||
| Nonresponder | — | 35 | 29 | 1.00 (ref) | ||
| Responder | 3.4 (1.96-7.6) | 80 | 40 | 1.20 (0.7-2.05) | .48 | |
| >50 | ||||||
| Nonresponder | — | 68 | 49 | 1.00 (ref) | ||
| Responder | 5.7 (2.2-12.1) | 47 | 20 | 0.97 (0.57-1.67) | .93 | |
| >75 | ||||||
| Nonresponder | — | 97 | 62 | 1.00 (ref) | ||
| Responder | 8.4 (3.6-13.6) | 18 | 7 | 1.38 (0.63-3.02) | .41 | |
| >90 | ||||||
| Nonresponder | — | 106 | 63 | 1.00 (ref) | ||
| Responder | 12.3 (4.4-19.8) | 9 | 4 | 2.16 (0.82-5.71) | .15 |
| Response criteria (% SMIC reduction) . | Response status . | Median (IQR) time to response, mo . | Number at risk . | Number of deaths . | HR (95% CI) . | P . |
|---|---|---|---|---|---|---|
| 115 | 69 | |||||
| >25 | ||||||
| Nonresponder | — | 35 | 29 | 1.00 (ref) | ||
| Responder | 3.4 (1.96-7.6) | 80 | 40 | 1.20 (0.7-2.05) | .48 | |
| >50 | ||||||
| Nonresponder | — | 68 | 49 | 1.00 (ref) | ||
| Responder | 5.7 (2.2-12.1) | 47 | 20 | 0.97 (0.57-1.67) | .93 | |
| >75 | ||||||
| Nonresponder | — | 97 | 62 | 1.00 (ref) | ||
| Responder | 8.4 (3.6-13.6) | 18 | 7 | 1.38 (0.63-3.02) | .41 | |
| >90 | ||||||
| Nonresponder | — | 106 | 63 | 1.00 (ref) | ||
| Responder | 12.3 (4.4-19.8) | 9 | 4 | 2.16 (0.82-5.71) | .15 |