Adjusted probabilities of outcomes in CML patients aged 18 to 60 years undergoing allo-HCT using MAC vs RIC, 2007-2014
| . | MAC (n = 1204) . | RIC (n = 191) . | . | ||
|---|---|---|---|---|---|
| Outcomes . | No. of patients (evaluable) . | Probability (95% CI), % . | No. of patients (evaluable) . | Probability (95% CI), % . | P . |
| OS, y | 1204 | 191 | |||
| 1 | 831 | 71 (68-73) | 133 | 72 (66-78) | .61 |
| 3 | 501 | 58 (55-60) | 86 | 58 (51-65) | .91 |
| 5 | 272 | 53 (50-56) | 49 | 53 (45-60) | .98 |
| LFS, y | 1190 | 191 | |||
| 1 | 731 | 63 (60-66) | 106 | 58 (51-65) | .15 |
| 3 | 423 | 50 (47-53) | 70 | 46 (39-53) | .31 |
| 5 | 222 | 44 (41-47) | 40 | 43 (36-51) | .81 |
| Relapse, y | 1190 | 191 | |||
| 1 | 731 | 16 (14-18) | 106 | 21 (16-27) | .10 |
| 3 | 423 | 23 (21-26) | 70 | 25 (19-31) | .49 |
| 5 | 222 | 26 (23-28) | 40 | 25 (19-31) | .96 |
| NRM, y | 1190 | 191 | |||
| 1 | 731 | 21 (18-23) | 106 | 19 (14-24) | .50 |
| 3 | 423 | 28 (25-30) | 70 | 26 (20-33) | .71 |
| 5 | 222 | 32 (29-35) | 40 | 29 (22-36) | .53 |
| cGVHD, y | 1182 | 188 | |||
| 1 | 316 | 50 (47-53) | 64 | 41 (33-48) | .02 |
| 3 | 122 | 58 (55-61) | 27 | 51 (43-58) | .08 |
| 5 | 57 | 59 (56-62) | 16 | 51 (44-59) | .07 |
| . | MAC (n = 1204) . | RIC (n = 191) . | . | ||
|---|---|---|---|---|---|
| Outcomes . | No. of patients (evaluable) . | Probability (95% CI), % . | No. of patients (evaluable) . | Probability (95% CI), % . | P . |
| OS, y | 1204 | 191 | |||
| 1 | 831 | 71 (68-73) | 133 | 72 (66-78) | .61 |
| 3 | 501 | 58 (55-60) | 86 | 58 (51-65) | .91 |
| 5 | 272 | 53 (50-56) | 49 | 53 (45-60) | .98 |
| LFS, y | 1190 | 191 | |||
| 1 | 731 | 63 (60-66) | 106 | 58 (51-65) | .15 |
| 3 | 423 | 50 (47-53) | 70 | 46 (39-53) | .31 |
| 5 | 222 | 44 (41-47) | 40 | 43 (36-51) | .81 |
| Relapse, y | 1190 | 191 | |||
| 1 | 731 | 16 (14-18) | 106 | 21 (16-27) | .10 |
| 3 | 423 | 23 (21-26) | 70 | 25 (19-31) | .49 |
| 5 | 222 | 26 (23-28) | 40 | 25 (19-31) | .96 |
| NRM, y | 1190 | 191 | |||
| 1 | 731 | 21 (18-23) | 106 | 19 (14-24) | .50 |
| 3 | 423 | 28 (25-30) | 70 | 26 (20-33) | .71 |
| 5 | 222 | 32 (29-35) | 40 | 29 (22-36) | .53 |
| cGVHD, y | 1182 | 188 | |||
| 1 | 316 | 50 (47-53) | 64 | 41 (33-48) | .02 |
| 3 | 122 | 58 (55-61) | 27 | 51 (43-58) | .08 |
| 5 | 57 | 59 (56-62) | 16 | 51 (44-59) | .07 |