Multivariate analysis for OS
| Variable . | HR . | 95% CI . | P . |
|---|---|---|---|
| Number of mutations | <.0001 | ||
| 0/1 | 1.00 | — | |
| 2/3 | 2.43 | 1.21-4.88 | |
| ≥4 | 5.51 | 2.50-12.15 | |
| TP53 mutation | |||
| No | 1.00 | — | .04 |
| Yes | 1.91 | 1.02-3.56 | |
| Age, y | 0.99 | 0.96-1.01 | .27 |
| Albumin level, g/L | 0.91 | 0.86-0.96 | .0004 |
| Blasts in PB, % | 1.02 | 1.01-1.02 | .0001 |
| Number of cytogenetic abnormalities | .01 | ||
| 0 | 1.00 | — | |
| 1 | 1.31 | 0.67-2.58 | |
| 2 | 1.95 | 0.92-4.15 | |
| ≥3 | 3.63 | 1.77-7.44 | |
| Missing | 2.15 | 1.11-4.15 | |
| Treatment intent | <.0001 | ||
| Intensive | 1.00 | — | |
| Nonintensive | 0.99 | 0.49-1.98 | |
| BSC | 3.99 | 2.02-7.92 |
| Variable . | HR . | 95% CI . | P . |
|---|---|---|---|
| Number of mutations | <.0001 | ||
| 0/1 | 1.00 | — | |
| 2/3 | 2.43 | 1.21-4.88 | |
| ≥4 | 5.51 | 2.50-12.15 | |
| TP53 mutation | |||
| No | 1.00 | — | .04 |
| Yes | 1.91 | 1.02-3.56 | |
| Age, y | 0.99 | 0.96-1.01 | .27 |
| Albumin level, g/L | 0.91 | 0.86-0.96 | .0004 |
| Blasts in PB, % | 1.02 | 1.01-1.02 | .0001 |
| Number of cytogenetic abnormalities | .01 | ||
| 0 | 1.00 | — | |
| 1 | 1.31 | 0.67-2.58 | |
| 2 | 1.95 | 0.92-4.15 | |
| ≥3 | 3.63 | 1.77-7.44 | |
| Missing | 2.15 | 1.11-4.15 | |
| Treatment intent | <.0001 | ||
| Intensive | 1.00 | — | |
| Nonintensive | 0.99 | 0.49-1.98 | |
| BSC | 3.99 | 2.02-7.92 |