Table 4. PRCA in patients with and... | American Society of Hematology

Table 4.

PRCA in patients with and without STAT3 mutations

	PRCA with STAT3 mutation, n = 15	PRCA without STAT3 mutation, n = 14	P
Age, median (range), y	63 (20-74)	73 (48-82)	.026*
Male, n (%)	3 (20)	5 (36)	.43
WBC, median (range), ×10⁹/L	4.31 (2.25-19.1)	4.73 (2.88-10.9)	.81
Neutrophils, median (range), ×10⁹/L	1.57 (0.67-13.2)	2.92 (0.72-8.74)	.13
Lymphocytes, median (range), ×10⁹/L	2.83 (0.50-7.50)	1.50 (0.31-4.12)	.044*
CD8⁺ T cells, median (range), ×10⁹/L	2.30 (0.22-5.51)	0.34 (0.20-3.33)	.0034*
Hemoglobin, median (range), g/L	75 (42-100)	62 (40-92)	.045*
Reticulocytes, median (range), ×10⁹/L	15.9 (0-27.8)	7.3 (2.3-16.7)	.13
Platelets, median (range), ×10⁹/L	295 (113-584)	300 (168-426)	.62
LD, median (range), IU/L	198 (159-350)	193 (137-351)	.74
Erythroblasts in BM, median (range), %	1.2 (0.2-4.3)	0.6 (0-5.2)	.53
TCRγ monoclonality	11/15	3/14	.0092*
Skewed TCRβ repertoire	9/10	0/6	.00087*
Refractory to CsA	9/13†	0/8	.0046*

	PRCA with STAT3 mutation, n = 15	PRCA without STAT3 mutation, n = 14	P
Age, median (range), y	63 (20-74)	73 (48-82)	.026*
Male, n (%)	3 (20)	5 (36)	.43
WBC, median (range), ×10⁹/L	4.31 (2.25-19.1)	4.73 (2.88-10.9)	.81
Neutrophils, median (range), ×10⁹/L	1.57 (0.67-13.2)	2.92 (0.72-8.74)	.13
Lymphocytes, median (range), ×10⁹/L	2.83 (0.50-7.50)	1.50 (0.31-4.12)	.044*
CD8⁺ T cells, median (range), ×10⁹/L	2.30 (0.22-5.51)	0.34 (0.20-3.33)	.0034*
Hemoglobin, median (range), g/L	75 (42-100)	62 (40-92)	.045*
Reticulocytes, median (range), ×10⁹/L	15.9 (0-27.8)	7.3 (2.3-16.7)	.13
Platelets, median (range), ×10⁹/L	295 (113-584)	300 (168-426)	.62
LD, median (range), IU/L	198 (159-350)	193 (137-351)	.74
Erythroblasts in BM, median (range), %	1.2 (0.2-4.3)	0.6 (0-5.2)	.53
TCRγ monoclonality	11/15	3/14	.0092*
Skewed TCRβ repertoire	9/10	0/6	.00087*
Refractory to CsA	9/13†	0/8	.0046*

Significantly different.

Seven patients were refractory to CsA, and 2 became secondarily resistant to CsA.