Table 2. The patients with STAT3... | American Society of Hematology

Table 2.

The patients with STAT3 mutations

Cohort	UPN	Cause of PRCA	STAT3 mutation
Cohort	UPN	Cause of PRCA	Allele-specific PCR	Amplicon (% PB or BM MNCs)	Amplicon (% CD8⁺ T)
Nagano/Kanazawa	47	Idiopathic	Y640F, D661Y	Y640F (2.9), D661Y (7.3)	Y640F (6), D661Y (13.7)
	166	Idiopathic	—	G618R (7.8), D698H (2)	NT
	182	CD, SjS	—	R152W (48.9)	NT
	243	Idiopathic	—	—	D661V (1.9)
	245	Thymoma	Y640F	Y640F (2.2)	Y640F (15.8)
	399	Idiopathic	—	S614R (9.1), Y640F (2.3)	NT
	3	T-LGLL	Y640F, D661Y	Y640F (5.6), D661Y (1.1)	NT
	8	T-LGLL	D661Y	D661Y (0.96)*	NT
	13	T-LGLL	D661Y	D661Y (0.57)*	NT
	37	T-LGLL	Y640F	Y640F (3.1)	NT
	170	T-LGLL	D661Y	D661Y (1.2)	S614R (1.5),† D661Y (1.2)†
	192	T-LGLL	—	D661H (4.8)	NT
	194	T-LGLL	—	—	Y640F (1.1)
	291	T-LGLL	D661Y	D661Y (2.5)	D661Y (3)
	293	T-LGLL	—	—	Y640F (2.5)
Akita	452	Thymoma	—	F174V (1.9), S614R (8)	NT
	453	Idiopathic	Y640F	D170G (6.4), Y640F (1.5)	NT
	455	T-LGLL	—	S614R (25.9)	NT

Cohort	UPN	Cause of PRCA	STAT3 mutation
Cohort	UPN	Cause of PRCA	Allele-specific PCR	Amplicon (% PB or BM MNCs)	Amplicon (% CD8⁺ T)
Nagano/Kanazawa	47	Idiopathic	Y640F, D661Y	Y640F (2.9), D661Y (7.3)	Y640F (6), D661Y (13.7)
	166	Idiopathic	—	G618R (7.8), D698H (2)	NT
	182	CD, SjS	—	R152W (48.9)	NT
	243	Idiopathic	—	—	D661V (1.9)
	245	Thymoma	Y640F	Y640F (2.2)	Y640F (15.8)
	399	Idiopathic	—	S614R (9.1), Y640F (2.3)	NT
	3	T-LGLL	Y640F, D661Y	Y640F (5.6), D661Y (1.1)	NT
	8	T-LGLL	D661Y	D661Y (0.96)*	NT
	13	T-LGLL	D661Y	D661Y (0.57)*	NT
	37	T-LGLL	Y640F	Y640F (3.1)	NT
	170	T-LGLL	D661Y	D661Y (1.2)	S614R (1.5),† D661Y (1.2)†
	192	T-LGLL	—	D661H (4.8)	NT
	194	T-LGLL	—	—	Y640F (1.1)
	291	T-LGLL	D661Y	D661Y (2.5)	D661Y (3)
	293	T-LGLL	—	—	Y640F (2.5)
Akita	452	Thymoma	—	F174V (1.9), S614R (8)	NT
	453	Idiopathic	Y640F	D170G (6.4), Y640F (1.5)	NT
	455	T-LGLL	—	S614R (25.9)	NT

—, not detected; CD, Crohn's disease; NT, not tested; PB, peripheral blood; SjS, Sjögren syndrome; UPN, unique patient number.

The percentage of STAT3-mutated DNA, as determined by an allele-specific quantitative PCR.

CD8⁺ T cells were sorted from BM MNCs.