Complement markers by TA-TMA status at GVHD onset and 2 to 6 weeks later
| Markers (complement pathway) . | Normal values, ng/dL . | TA-TMA + GVHD . | GVHD only . | . | ||
|---|---|---|---|---|---|---|
| n . | Median (range) . | n . | Median (range) . | P . | ||
| GVHD onset | ||||||
| BBPlus (alternative) | 244-961 | 21 | 403.2 (124.5-2323.0) | 14 | 481.5 (239.8-1816.6) | .87 |
| C5b-9 (terminal) | 34-248 | 21 | 289.8 (147.5-643.0) | 14 | 263.7 (169.1-518.3) | .46 |
| C4d (classical) | 279-1846 | 21 | 2854.8 (962.0-5016.2) | 14 | 2678.6 (1399.7-6205.7) | .74 |
| C5a (terminal) | 19-48 | 21 | 52.0 (13.2-105.2) | 14 | 42.5 (18.8-89.1) | .71 |
| 2-6 wk after GVHD onset | ||||||
| BBPlus (alternative) | 244-961 | 29 | 600.0 (130.6-2119.0) | 12 | 209.3 (94.5-908.7) | .0045 |
| C5b-9 (terminal) | 34-248 | 29 | 425.9 (193.2-860.0) | 12 | 258.4 (100.0-697.3) | .029 |
| C4d (classical) | 279-1846 | 29 | 1899.9 (420.0-4717.1) | 12 | 1558.7 (546.6-4096.4) | .55 |
| C5a (terminal) | 19-48 | 29 | 45.0 (12.4-154.0) | 12 | 38.8 (24.4-48.3) | .53 |
| Markers (complement pathway) . | Normal values, ng/dL . | TA-TMA + GVHD . | GVHD only . | . | ||
|---|---|---|---|---|---|---|
| n . | Median (range) . | n . | Median (range) . | P . | ||
| GVHD onset | ||||||
| BBPlus (alternative) | 244-961 | 21 | 403.2 (124.5-2323.0) | 14 | 481.5 (239.8-1816.6) | .87 |
| C5b-9 (terminal) | 34-248 | 21 | 289.8 (147.5-643.0) | 14 | 263.7 (169.1-518.3) | .46 |
| C4d (classical) | 279-1846 | 21 | 2854.8 (962.0-5016.2) | 14 | 2678.6 (1399.7-6205.7) | .74 |
| C5a (terminal) | 19-48 | 21 | 52.0 (13.2-105.2) | 14 | 42.5 (18.8-89.1) | .71 |
| 2-6 wk after GVHD onset | ||||||
| BBPlus (alternative) | 244-961 | 29 | 600.0 (130.6-2119.0) | 12 | 209.3 (94.5-908.7) | .0045 |
| C5b-9 (terminal) | 34-248 | 29 | 425.9 (193.2-860.0) | 12 | 258.4 (100.0-697.3) | .029 |
| C4d (classical) | 279-1846 | 29 | 1899.9 (420.0-4717.1) | 12 | 1558.7 (546.6-4096.4) | .55 |
| C5a (terminal) | 19-48 | 29 | 45.0 (12.4-154.0) | 12 | 38.8 (24.4-48.3) | .53 |