Presence of histology findings by GVHD steroid response
| Histology finding . | Steroid-refractory GVHD, n = 32 . | Steroid-dependent GVHD, n = 12 . | Steroid-responsive GVHD, n = 22 . | P . | |||||
|---|---|---|---|---|---|---|---|---|---|
| n . | % . | n . | % . | n . | % . | Overall . | Refractory vs responsive . | Refractory vs dependent . | |
| TMA-associated findings | |||||||||
| Mucosal hemorrhage | 32 | 100.0 | 10 | 83.3 | 21 | 95.5 | .04 | .41 | .07 |
| Loss of glands | 19 | 59.4 | 5 | 41.7 | 7 | 31.8 | .13 | .06 | .33 |
| Intraluminal schistocytes | 2 | 6.3 | 0 | 0.0 | 0 | 0.0 | .67 | .51 | .99 |
| Intraluminal fibrin/microthrombi | 4 | 12.5 | 2 | 16.7 | 4 | 18.2 | .82 | .70 | .66 |
| Endothelial cell swelling | 20 | 62.5 | 4 | 33.3 | 8 | 36.4 | .10 | .10 | .10 |
| Endothelial cell separation | 5 | 15.6 | 1 | 8.3 | 1 | 4.5 | .59 | .38 | .99 |
| Areas of totally denuded mucosa | 17 | 53.1 | 4 | 33.3 | 7 | 31.8 | .26 | .17 | .32 |
| GVHD-associated findings | |||||||||
| Mucosal erosion | 14 | 43.8 | 2 | 16.7 | 3 | 13.6 | .04 | .04 | .16 |
| Lamina propria inflammatory infiltrate | 7 | 21.9 | 2 | 16.7 | 2 | 9.1 | .46 | .28 | .99 |
| Cystic gland dilation | 16 | 50.0 | 4 | 33.3 | 8 | 36.4 | .57 | .41 | .50 |
| Apoptotic crypt abscesses | 20 | 62.5 | 5 | 41.7 | 12 | 54.5 | .49 | .59 | .31 |
| Neutrophilic crypt abscesses | 10 | 31.3 | 1 | 8.3 | 6 | 27.3 | .32 | .99 | .24 |
| Acute inflammation of lamina propria | 15 | 46.9 | 6 | 50.0 | 9 | 40.9 | .85 | .78 | .99 |
| Ulceration | 7 | 21.9 | 3 | 25.0 | 2 | 9.1 | .37 | .28 | .99 |
| Depth of epithelial cell apoptosis (crypt/gland) | .01 | .01 | .37 | ||||||
| One-third depth | 14 | 43.8 | 8 | 66.7 | 12 | 54.6 | |||
| Two-thirds depth | 6 | 18.8 | 1 | 8.3 | 9 | 40.9 | |||
| Full depth | 11 | 34.4 | 2 | 16.7 | 0 | 0.0 | |||
| None | 1 | 3.1 | 1 | 8.3 | 1 | 4.6 | |||
| Infection-associated findings | |||||||||
| CMV inclusion bodies or +IHC stain | 0 | 0.0 | 1 | 8.3 | 2 | 9.1 | .18 | .16 | .27 |
| Adenovirus inclusion bodies or +IHC stain | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | |||
| Histology finding . | Steroid-refractory GVHD, n = 32 . | Steroid-dependent GVHD, n = 12 . | Steroid-responsive GVHD, n = 22 . | P . | |||||
|---|---|---|---|---|---|---|---|---|---|
| n . | % . | n . | % . | n . | % . | Overall . | Refractory vs responsive . | Refractory vs dependent . | |
| TMA-associated findings | |||||||||
| Mucosal hemorrhage | 32 | 100.0 | 10 | 83.3 | 21 | 95.5 | .04 | .41 | .07 |
| Loss of glands | 19 | 59.4 | 5 | 41.7 | 7 | 31.8 | .13 | .06 | .33 |
| Intraluminal schistocytes | 2 | 6.3 | 0 | 0.0 | 0 | 0.0 | .67 | .51 | .99 |
| Intraluminal fibrin/microthrombi | 4 | 12.5 | 2 | 16.7 | 4 | 18.2 | .82 | .70 | .66 |
| Endothelial cell swelling | 20 | 62.5 | 4 | 33.3 | 8 | 36.4 | .10 | .10 | .10 |
| Endothelial cell separation | 5 | 15.6 | 1 | 8.3 | 1 | 4.5 | .59 | .38 | .99 |
| Areas of totally denuded mucosa | 17 | 53.1 | 4 | 33.3 | 7 | 31.8 | .26 | .17 | .32 |
| GVHD-associated findings | |||||||||
| Mucosal erosion | 14 | 43.8 | 2 | 16.7 | 3 | 13.6 | .04 | .04 | .16 |
| Lamina propria inflammatory infiltrate | 7 | 21.9 | 2 | 16.7 | 2 | 9.1 | .46 | .28 | .99 |
| Cystic gland dilation | 16 | 50.0 | 4 | 33.3 | 8 | 36.4 | .57 | .41 | .50 |
| Apoptotic crypt abscesses | 20 | 62.5 | 5 | 41.7 | 12 | 54.5 | .49 | .59 | .31 |
| Neutrophilic crypt abscesses | 10 | 31.3 | 1 | 8.3 | 6 | 27.3 | .32 | .99 | .24 |
| Acute inflammation of lamina propria | 15 | 46.9 | 6 | 50.0 | 9 | 40.9 | .85 | .78 | .99 |
| Ulceration | 7 | 21.9 | 3 | 25.0 | 2 | 9.1 | .37 | .28 | .99 |
| Depth of epithelial cell apoptosis (crypt/gland) | .01 | .01 | .37 | ||||||
| One-third depth | 14 | 43.8 | 8 | 66.7 | 12 | 54.6 | |||
| Two-thirds depth | 6 | 18.8 | 1 | 8.3 | 9 | 40.9 | |||
| Full depth | 11 | 34.4 | 2 | 16.7 | 0 | 0.0 | |||
| None | 1 | 3.1 | 1 | 8.3 | 1 | 4.6 | |||
| Infection-associated findings | |||||||||
| CMV inclusion bodies or +IHC stain | 0 | 0.0 | 1 | 8.3 | 2 | 9.1 | .18 | .16 | .27 |
| Adenovirus inclusion bodies or +IHC stain | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | |||
IHC, immunhistochemistry.