Definitions of TA-TMA criteria and GVHD steroid responses
| . | Definition . |
|---|---|
| TMA criteria | |
| Anemia/thrombocytopenia | Received >2 transfusions of platelets and/or packed red blood cells after initial GI biopsy |
| Hemolysis | Documentation of schistocytes or nucleated red blood cells on at least 2 consecutive tests |
| Renal end-organ damage | Evidence of new or worsening hypertension based on documentation or addition/titration of medication, acute kidney injury based on Acute Kidney Injury Network criteria, or proteinuria of ≥30 mg/dL by urinalysis, spot protein/creatinine ratio, or 24-hour urine collection |
| GVHD steroid responses | |
| Steroid-refractory | Lack of clinical response after 7 days of at least 2 mg/kg per day of methylprednisolone or equivalent dose |
| Steroid-dependent | Requirement for a second course of at least 1 mg/kg per day after an attempt to taper |
| Steroid-responsive | Any case not meeting criteria for steroid-refractory or steroid-dependent |
| . | Definition . |
|---|---|
| TMA criteria | |
| Anemia/thrombocytopenia | Received >2 transfusions of platelets and/or packed red blood cells after initial GI biopsy |
| Hemolysis | Documentation of schistocytes or nucleated red blood cells on at least 2 consecutive tests |
| Renal end-organ damage | Evidence of new or worsening hypertension based on documentation or addition/titration of medication, acute kidney injury based on Acute Kidney Injury Network criteria, or proteinuria of ≥30 mg/dL by urinalysis, spot protein/creatinine ratio, or 24-hour urine collection |
| GVHD steroid responses | |
| Steroid-refractory | Lack of clinical response after 7 days of at least 2 mg/kg per day of methylprednisolone or equivalent dose |
| Steroid-dependent | Requirement for a second course of at least 1 mg/kg per day after an attempt to taper |
| Steroid-responsive | Any case not meeting criteria for steroid-refractory or steroid-dependent |