Frequency of cytogenetic iFISH aberrations depending on disease (PC-AL vs PC–non-AL) and stage of plasma cell dyscrasia (MGUS/SMM/MM)
| . | PC-AL . | PC–non-AL . | P (PC-AL vs PC–non-AL) . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| n/N (%) . | P . | n/N (%) . | P . | ||||||||
| Total (n = 544) . | MGUS (n = 164) . | SMM (n = 345) . | MM (n = 35) . | Total (n = 519) . | MGUS (n = 62) . | SMM (n = 156) . | MM (n = 301) . | ||||
| Translocations | |||||||||||
| t(11;14) | 331/544 (60.8) | 117/164 (71.3) | 200/345 (58.0) | 14/35 (40.0) | .001 | 76/519 (14.6) | 4/62 (6.5) | 7/156 (4.5) | 65/301 (21.6) | <.001 | <.001 |
| t(4;14) | 19/544 (3.5) | 1/164 (0.6) | 16/345 (4.6) | 2/35 (5.7) | .17 | 86/519 (16.6) | 6/62 (9.7) | 33/156 (21.2) | 47/301 (15.6) | .81 | <.001 |
| t(14;16) | 13/543 (2.4) | 2/164 (1.2) | 11/344 (3.2) | 0/35 (0) | .58 | 30/511 (5.5) | 9/60 (15.0) | 15/153 (9.8) | 6/298 (2.0) | <.001 | <.001 |
| IgH unknown | 94/541 (17.4) | 25/164 (15.2) | 286/343 (16.6) | 12/34 (35.3) | .25 | 166/489 (33.9) | 37/61 (60.7) | 75/153 (49.0) | 54/275 (19.6) | <.001 | <.001 |
| Gains | |||||||||||
| 1q21 | 167/544 (30.7) | 40/164 (24.4) | 115/345 (33.3) | 12/35 (34.3) | .25 | 195/519 (37.6) | 23/62 (37.1) | 69/156 (44.2) | 103/301 (34.2) | .75 | .034 |
| 5p15/5q35 | 83/533 (15.6) | 17/160 (10.6) | 54/341 (15.8) | 12/32 (37.5) | .013 | 136/367 (37.1) | 17/54 (31.5) | 54/148 (36.5) | 65/165 (39.4) | .75 | <.001 |
| 9q34 | 172/543 (31.7) | 42/163 (25.8) | 112/345 (32.5) | 18/35 (51.4) | .054 | 283/517 (54.7) | 31/62 (50.0) | 80/156 (51.3) | 172/299 (57.5) | .75 | <.001 |
| 11q22.3 | 211/544 (38.8) | 71/164 (43.3) | 128/345 (37.1) | 12/35 (34.3) | .31 | 224/519 (43.2) | 15/62 (24.2) | 58/156 (37.2) | 151/301 (50.2) | <.001 | .59 |
| 11q23 | |||||||||||
| 15q22 | 97/544 (17.9) | 19/163 (11.7) | 64/344 (18.6) | 14/35 (40.0) | .004 | 245/517 (47.5) | 21/62 (33.9) | 65/156 (41.7) | 159/299 (53.2) | .01 | <.001 |
| 19q13 | 102/542 (18.8) | 21/163 (12.9) | 70/344 (20.3) | 11/35 (31.4) | .054 | 258/519 (49.7) | 23/62 (37.1) | 73/156 (46.8) | 162/301 (53.8) | .067 | <.001 |
| Deletions | |||||||||||
| 8p21 | 38/534 (7.1) | 6/161 (3.7) | 28/338 (8.3) | 4/35 (11.4) | .22 | 108/519 (20.8) | 3/62 (4.8) | 29/156 (18.6) | 76/301 (25.2) | .003 | .034 |
| 13q14 | 209/544 (38.4) | 56/164 (34.1) | 133/345 (38.6) | 20/35 (57.1) | .22 | 264/519 (50.9) | 2 /62 (41.9) | 79/156 (50.6) | 159/301 (52.8) | .75 | .071 |
| 17p13 | 16/544 (2.9) | 3/164 (1.8) | 10/345 (2.9) | 3/35 (8.6) | .25 | 47/519 (9.1) | 1/62 (1.6) | 10/156 (6.4) | 36/301 (12.0) | .024 | .19 |
| . | PC-AL . | PC–non-AL . | P (PC-AL vs PC–non-AL) . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| n/N (%) . | P . | n/N (%) . | P . | ||||||||
| Total (n = 544) . | MGUS (n = 164) . | SMM (n = 345) . | MM (n = 35) . | Total (n = 519) . | MGUS (n = 62) . | SMM (n = 156) . | MM (n = 301) . | ||||
| Translocations | |||||||||||
| t(11;14) | 331/544 (60.8) | 117/164 (71.3) | 200/345 (58.0) | 14/35 (40.0) | .001 | 76/519 (14.6) | 4/62 (6.5) | 7/156 (4.5) | 65/301 (21.6) | <.001 | <.001 |
| t(4;14) | 19/544 (3.5) | 1/164 (0.6) | 16/345 (4.6) | 2/35 (5.7) | .17 | 86/519 (16.6) | 6/62 (9.7) | 33/156 (21.2) | 47/301 (15.6) | .81 | <.001 |
| t(14;16) | 13/543 (2.4) | 2/164 (1.2) | 11/344 (3.2) | 0/35 (0) | .58 | 30/511 (5.5) | 9/60 (15.0) | 15/153 (9.8) | 6/298 (2.0) | <.001 | <.001 |
| IgH unknown | 94/541 (17.4) | 25/164 (15.2) | 286/343 (16.6) | 12/34 (35.3) | .25 | 166/489 (33.9) | 37/61 (60.7) | 75/153 (49.0) | 54/275 (19.6) | <.001 | <.001 |
| Gains | |||||||||||
| 1q21 | 167/544 (30.7) | 40/164 (24.4) | 115/345 (33.3) | 12/35 (34.3) | .25 | 195/519 (37.6) | 23/62 (37.1) | 69/156 (44.2) | 103/301 (34.2) | .75 | .034 |
| 5p15/5q35 | 83/533 (15.6) | 17/160 (10.6) | 54/341 (15.8) | 12/32 (37.5) | .013 | 136/367 (37.1) | 17/54 (31.5) | 54/148 (36.5) | 65/165 (39.4) | .75 | <.001 |
| 9q34 | 172/543 (31.7) | 42/163 (25.8) | 112/345 (32.5) | 18/35 (51.4) | .054 | 283/517 (54.7) | 31/62 (50.0) | 80/156 (51.3) | 172/299 (57.5) | .75 | <.001 |
| 11q22.3 | 211/544 (38.8) | 71/164 (43.3) | 128/345 (37.1) | 12/35 (34.3) | .31 | 224/519 (43.2) | 15/62 (24.2) | 58/156 (37.2) | 151/301 (50.2) | <.001 | .59 |
| 11q23 | |||||||||||
| 15q22 | 97/544 (17.9) | 19/163 (11.7) | 64/344 (18.6) | 14/35 (40.0) | .004 | 245/517 (47.5) | 21/62 (33.9) | 65/156 (41.7) | 159/299 (53.2) | .01 | <.001 |
| 19q13 | 102/542 (18.8) | 21/163 (12.9) | 70/344 (20.3) | 11/35 (31.4) | .054 | 258/519 (49.7) | 23/62 (37.1) | 73/156 (46.8) | 162/301 (53.8) | .067 | <.001 |
| Deletions | |||||||||||
| 8p21 | 38/534 (7.1) | 6/161 (3.7) | 28/338 (8.3) | 4/35 (11.4) | .22 | 108/519 (20.8) | 3/62 (4.8) | 29/156 (18.6) | 76/301 (25.2) | .003 | .034 |
| 13q14 | 209/544 (38.4) | 56/164 (34.1) | 133/345 (38.6) | 20/35 (57.1) | .22 | 264/519 (50.9) | 2 /62 (41.9) | 79/156 (50.6) | 159/301 (52.8) | .75 | .071 |
| 17p13 | 16/544 (2.9) | 3/164 (1.8) | 10/345 (2.9) | 3/35 (8.6) | .25 | 47/519 (9.1) | 1/62 (1.6) | 10/156 (6.4) | 36/301 (12.0) | .024 | .19 |
Frequency of cytogenetic aberrations in the AL amyloidosis group (PC-AL) as compared with the MGUS/SMM/MM control group (PC–non-AL group). Frequencies are also detailed for the respective stages of plasma cell dyscrasia. P values indicate changes of the frequency of the respective aberrations depending on the stage of plasma cell dyscrasia. The P value in the last column addresses the frequency difference between the PC-AL and PC–non-AL groupS (adjusted for the respective frequencies of MGUS/SMM/MM in both groups via logistic regression). All P values were adjusted for multiple testing across probes using Holm correction to control the family-wise error rate.