Baseline characteristics and cell collection yield of patients
| Subject . | Age, y . | Sex . | No. VOE in last 2 y . | No. ACS in last 2 y . | History of splenectomy . | History of CNS event . | Resting CD34+* . | Plerixafor dose, μg/kg . | Peak CD34+, cells/μL . | Plerixafor to apheresis time, h . | CD34+ cells collected, ×106/kg . | Ideal predicted CD34+ yield, × 106/kg† . | CD34+ postselection recovery (purity), % . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 30 | M | 2 | 2 | No | Yes | 1,2 | 180 | 36 | 5:42 | 0.069 | 3.1 | 81, (32) |
| 2 | 19 | M | 0 | 0 | No | Yes | 3,3 | 180 | 65 | 5:20 | 0.616 | 5.1 | 54, (84) |
| 3 | 26 | M | 0 | 0 | No | No | 2,4 | 180 | 31 | 5:35 | 1.2 | 2.6 | 20‡, (68) |
| 4 | 25 | M | 0 | 0 | Yes | Yes | 10,31 | 240 | 290 | 3:55 | 24.53 | 26.8 | 59, (99) |
| 5 | 38 | M | 0 | 0 | Yes | Yes | 2,2 | 240 | 27 | 3:54 | 2.94 | 2.2 | 41, (94) |
| 6 | 25 | M | 0 | 0 | Yes | Yes | 5,8 | 240 | 156 | 3:54 | 16.38 | 13.1 | 61, (99) |
| Subject . | Age, y . | Sex . | No. VOE in last 2 y . | No. ACS in last 2 y . | History of splenectomy . | History of CNS event . | Resting CD34+* . | Plerixafor dose, μg/kg . | Peak CD34+, cells/μL . | Plerixafor to apheresis time, h . | CD34+ cells collected, ×106/kg . | Ideal predicted CD34+ yield, × 106/kg† . | CD34+ postselection recovery (purity), % . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 30 | M | 2 | 2 | No | Yes | 1,2 | 180 | 36 | 5:42 | 0.069 | 3.1 | 81, (32) |
| 2 | 19 | M | 0 | 0 | No | Yes | 3,3 | 180 | 65 | 5:20 | 0.616 | 5.1 | 54, (84) |
| 3 | 26 | M | 0 | 0 | No | No | 2,4 | 180 | 31 | 5:35 | 1.2 | 2.6 | 20‡, (68) |
| 4 | 25 | M | 0 | 0 | Yes | Yes | 10,31 | 240 | 290 | 3:55 | 24.53 | 26.8 | 59, (99) |
| 5 | 38 | M | 0 | 0 | Yes | Yes | 2,2 | 240 | 27 | 3:54 | 2.94 | 2.2 | 41, (94) |
| 6 | 25 | M | 0 | 0 | Yes | Yes | 5,8 | 240 | 156 | 3:54 | 16.38 | 13.1 | 61, (99) |
ACS, acute chest syndrome; CNS, central nervous system; VOE, vaso-occlusive episode.
Multiple resting CD34+ counts were measured, all within 3 months before Plx. Lowest and highest are depicted here.
Predicted ideal collection yields were calculated; see also right half of Figure 1F.
Technical deviation from standard selection protocol.