Characteristics of informative marrow samples
| Disease state . | Sex (no.) . | Age . | Tumor isotype-no. . | % myeloma cells in marrow . | Paraprotein (g/L)* . | STK (0-5 U/L) . | β2m (0-3 mg/L) . | IgH switch recombinations-no. . |
|---|---|---|---|---|---|---|---|---|
| Stable (4) | M (3) | 44-68 | all IgGκ | 26 ± 4 | IgG 34 ± 9 | 6.9 ± 2.7 | 2.0 ± 0.6 | illegitimate-1 |
| F (1) | (20-30) | (21-41) | (3.8-8.6) | (1.5-2.5) | legitimate only-3 | |||
| Progressive (17) | M (12) | 35-85 | IgGκ-9 | 57 ± 23 | IgG 43 ± 18 | 10.5 ± 6.5 | 6.5 ± 6.3 | illegitimate-11 |
| F (5) | IgGλ-2 | (25-99) | (26-72) | (2.0-26) | (2.0-24) | |||
| IgAκ-3 | legitimate only-6 | |||||||
| IgMλ-1 | IgA 28 ± 16 | |||||||
| κ-1 | (18-47) | |||||||
| λ-1 | ||||||||
| IgM 72 |
| Disease state . | Sex (no.) . | Age . | Tumor isotype-no. . | % myeloma cells in marrow . | Paraprotein (g/L)* . | STK (0-5 U/L) . | β2m (0-3 mg/L) . | IgH switch recombinations-no. . |
|---|---|---|---|---|---|---|---|---|
| Stable (4) | M (3) | 44-68 | all IgGκ | 26 ± 4 | IgG 34 ± 9 | 6.9 ± 2.7 | 2.0 ± 0.6 | illegitimate-1 |
| F (1) | (20-30) | (21-41) | (3.8-8.6) | (1.5-2.5) | legitimate only-3 | |||
| Progressive (17) | M (12) | 35-85 | IgGκ-9 | 57 ± 23 | IgG 43 ± 18 | 10.5 ± 6.5 | 6.5 ± 6.3 | illegitimate-11 |
| F (5) | IgGλ-2 | (25-99) | (26-72) | (2.0-26) | (2.0-24) | |||
| IgAκ-3 | legitimate only-6 | |||||||
| IgMλ-1 | IgA 28 ± 16 | |||||||
| κ-1 | (18-47) | |||||||
| λ-1 | ||||||||
| IgM 72 |
Immunoglobulin normal ranges (g/L): IgG 6.5-15; IgA 0.6-4; IgM 0.5-3.2. β2m indicates β2 microglobulin; STK, serum thymidine kinase.