Table 6. Toxicity UPN . Injection site... | American Society of Hematology

Table 6.

Toxicity

UPN	Injection site reaction	Systemic symptoms	Splenomegaly	Hypersplenism	Lowest platelet count	Leukoerythroblastic response	Left shift	Other	Completed study
21	no	no	yes	no	—	no	yes	—	yes
22	no	no	yes	no	—	no	yes	widening of diploic spaces	yes
23	no	headache, muscle aches	yes	no	—	yes	yes	—	no
24	no	nausea	yes	no	—	yes	yes	—	yes
25	no	no	yes	no	—	no	yes	—	yes
26	no	no	yes	no	—	yes	yes	—	yes
27	no	no	yes	yes	114	no	yes	—	yes
28	no	no	yes	yes	92	no	no	—	yes
31	no	no	yes	yes	85	no	yes	splenectomy	yes
32	no	no	yes	yes	82	no	yes	—	yes
33	no	bone pain	yes	yes	74	no	yes	—	yes
34	no	no	yes	no	—	no	no	—	yes
35	no	no	yes	no	—	no	yes	—	yes

UPN	Injection site reaction	Systemic symptoms	Splenomegaly	Hypersplenism	Lowest platelet count	Leukoerythroblastic response	Left shift	Other	Completed study
21	no	no	yes	no	—	no	yes	—	yes
22	no	no	yes	no	—	no	yes	widening of diploic spaces	yes
23	no	headache, muscle aches	yes	no	—	yes	yes	—	no
24	no	nausea	yes	no	—	yes	yes	—	yes
25	no	no	yes	no	—	no	yes	—	yes
26	no	no	yes	no	—	yes	yes	—	yes
27	no	no	yes	yes	114	no	yes	—	yes
28	no	no	yes	yes	92	no	no	—	yes
31	no	no	yes	yes	85	no	yes	splenectomy	yes
32	no	no	yes	yes	82	no	yes	—	yes
33	no	bone pain	yes	yes	74	no	yes	—	yes
34	no	no	yes	no	—	no	no	—	yes
35	no	no	yes	no	—	no	yes	—	yes

Toxicity was determined by review of patient diaries and case report forms. Hypersplenism was defined as a platelet count of less than 150 × 10⁹ cells/L on 2 consecutive complete blood counts.