Table 1. Statistical analysis of the... | American Society of Hematology

Table 1.

Statistical analysis of the relationship between lymphoblast glutathione levels and in vitro drug sensitivity in childhood acute lymphoblastic leukemia

Drug	No.	ρ^*	P^†	MWU test^‡P value
6-Mercaptopurine	51	−0.12	.40	.83
Thioguanine	55	−0.08	.56	.92
Dexamethasone	42	−0.18	.27	.29
Prednisolone	55	−0.10	.48	.63
Daunorubicin	57	0.01	.95	.46
Doxorubicin	44	−0.03	.87	.63
Asparaginase	58	0.17	.21	.31
Vincristine	56	0.25	.06	.04^1-153
Ifosfamide	17	0.46	.07	.03^1-153
Cytarabine	56	−0.08	.54	.64

Drug	No.	ρ^*	P^†	MWU test^‡P value
6-Mercaptopurine	51	−0.12	.40	.83
Thioguanine	55	−0.08	.56	.92
Dexamethasone	42	−0.18	.27	.29
Prednisolone	55	−0.10	.48	.63
Daunorubicin	57	0.01	.95	.46
Doxorubicin	44	−0.03	.87	.63
Asparaginase	58	0.17	.21	.31
Vincristine	56	0.25	.06	.04^1-153
Ifosfamide	17	0.46	.07	.03^1-153
Cytarabine	56	−0.08	.54	.64

The relationship between lymphoblast glutathione levels and the IC₅₀ for each cytotoxic drug studied was tested by means of the Spearman rank correlation and the Mann-Whitney test (MWU test). The IC₅₀ was defined as the lowest concentration of a drug required to kill 50% of cells in the MTT assay.

ρ = Spearman rank correlation coefficient.

†

P = Significance tested by 2-tailed test.

‡

For the Mann-Whitney test, the samples were grouped as high or low glutathione levels. A high glutathione level was defined as greater than the median for the cohort of samples analyzed.

F1-153

Significant P values.

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