Components of regimen that may facilitate long-term tolerance or engraftment potential
| Component of regimen . | Mode of action . |
|---|---|
| High levels of stem cells | Inherently tolerizing or proper number of modulatory cells |
| Nonablative host treatment | Minimize “cytokine storm” |
| Antigen presensitization and anti-CD40 ligand antibody blockade | Induce antigen-specific tolerance |
| Component of regimen . | Mode of action . |
|---|---|
| High levels of stem cells | Inherently tolerizing or proper number of modulatory cells |
| Nonablative host treatment | Minimize “cytokine storm” |
| Antigen presensitization and anti-CD40 ligand antibody blockade | Induce antigen-specific tolerance |