Table 2. Clinical and biologic profile... | American Society of Hematology

Table 2.

Clinical and biologic profile of R, I, and S patients

Characteristics	Resistant patients (R)^*	Intermediate patients (I)^†	Sensitive patients (S)^‡	P value	P value R vs I	P value I vs S	P value R vs S
Patients, No. (%)	38 (29)	46 (36)	45 (35)	—	—	—	—
Age, y	58 ± 16	56 ± 17	54 ± 19	NS^2-153	NS^2-155	NS^2-155	NS^2-155
WBC count at diagnosis (10⁹/L)	58 ± 16	56 ± 17	54 ± 19	NS^2-153	NS^2-155	NS^2-155	NS^2-155
LDH level (U/L)	1766 ± 1831	1680 ± 1696	1910 ± 2118	NS^2-153	NS^2-155	NS^2-155	NS^2-155
WHO performance status (No.)				NS^2-154	NS^2-154	NS^2-154	NS^2-154
0 or 1	28	34	32
≥2	10	12	13
Cytogenetic (No.)				.03^2-154	.01^2-154	NS^2-154	.02^2-154
Good	1/19	8/19	10/19
Intermediate	22/75	29/75	24/75
Poor	12/25	5/25	8/25
Failure or not done	3/10	4/10	3/10
CD34 no. (%)	36/38 (95)	31/46 (67)	20/45 (44)	<.0001^2-154	.002^2-154	.04^2-154	<.0001^2-154
CD65 no. (%)	4/28 (14)	15/37 (41)	18/36 (50)	.01^2-154	.03^2-154	NS^2-154	.003^2-154
Pgp expression (D value)	0.39 ± 0.24	0.29 ± 0.22	0.19 ± 0.20	.002^2-153	.05^2-155	.03^2-155	.0008^2-155
LC₅₀ DNR (10⁻⁸M)	94 ± 145	20 ± 25	12 ± 13	.02^2-153	.03^2-155	NS^2-155	.009^2-155
LC₅₀ etoposide (10⁻⁸M)	2131 ± 2858	1731 ± 2109	839 ± 887	.04^2-153	NS^2-155	.05^2-155	.01^2-155
LC₅₀ aracytine (10⁻⁸M)	1781 ± 3333	572 ± 472	444 ± 543	.02^2-153	.04^2-155	NS^2-155	.008^2-155
Rhodamine 123 (D value)	0.41 ± 0.17	0.10 ± 0.11	0.10 ± 0.08	<.0001^2-153	<.0001^2-155	NS^2-155	<.0001^2-155
Achievement of CR, no. (%)	21 (55)	30 (65)	39 (87)	.006^2-154	NS^2-154	.01^2-154	.001^2-154

Characteristics	Resistant patients (R)^*	Intermediate patients (I)^†	Sensitive patients (S)^‡	P value	P value R vs I	P value I vs S	P value R vs S
Patients, No. (%)	38 (29)	46 (36)	45 (35)	—	—	—	—
Age, y	58 ± 16	56 ± 17	54 ± 19	NS^2-153	NS^2-155	NS^2-155	NS^2-155
WBC count at diagnosis (10⁹/L)	58 ± 16	56 ± 17	54 ± 19	NS^2-153	NS^2-155	NS^2-155	NS^2-155
LDH level (U/L)	1766 ± 1831	1680 ± 1696	1910 ± 2118	NS^2-153	NS^2-155	NS^2-155	NS^2-155
WHO performance status (No.)				NS^2-154	NS^2-154	NS^2-154	NS^2-154
0 or 1	28	34	32
≥2	10	12	13
Cytogenetic (No.)				.03^2-154	.01^2-154	NS^2-154	.02^2-154
Good	1/19	8/19	10/19
Intermediate	22/75	29/75	24/75
Poor	12/25	5/25	8/25
Failure or not done	3/10	4/10	3/10
CD34 no. (%)	36/38 (95)	31/46 (67)	20/45 (44)	<.0001^2-154	.002^2-154	.04^2-154	<.0001^2-154
CD65 no. (%)	4/28 (14)	15/37 (41)	18/36 (50)	.01^2-154	.03^2-154	NS^2-154	.003^2-154
Pgp expression (D value)	0.39 ± 0.24	0.29 ± 0.22	0.19 ± 0.20	.002^2-153	.05^2-155	.03^2-155	.0008^2-155
LC₅₀ DNR (10⁻⁸M)	94 ± 145	20 ± 25	12 ± 13	.02^2-153	.03^2-155	NS^2-155	.009^2-155
LC₅₀ etoposide (10⁻⁸M)	2131 ± 2858	1731 ± 2109	839 ± 887	.04^2-153	NS^2-155	.05^2-155	.01^2-155
LC₅₀ aracytine (10⁻⁸M)	1781 ± 3333	572 ± 472	444 ± 543	.02^2-153	.04^2-155	NS^2-155	.008^2-155
Rhodamine 123 (D value)	0.41 ± 0.17	0.10 ± 0.11	0.10 ± 0.08	<.0001^2-153	<.0001^2-155	NS^2-155	<.0001^2-155
Achievement of CR, no. (%)	21 (55)	30 (65)	39 (87)	.006^2-154	NS^2-154	.01^2-154	.001^2-154

NS indicates not significant.

Samples with functional Pgp in both green and red fluorescences.

Samples with functional Pgp in red fluorescence and samples with no functional Pgp in green fluorescence.

Samples with no functional Pgp in both green and red fluorescences.

Using the Kruskal-Wallis test.

Using the Mann-Whitney U test.

Using the Fisher exact test.