ISCL/EORTC proposal on TNM classification of cutaneous lymphoma other than MF/SS
| T: skin |
| T1: solitary skin involvement |
| T1a: solitary lesion <5-cm diameter |
| T1b: solitary >5-cm diameter |
| T2: regional skin involvement: multiple lesions limited to 1 body region or 2 contiguous body regions* |
| T2a: all-disease-encompassing in a <15-cm diameter circular area |
| T2b: all-disease-encompassing in a >15- and <30-cm diameter circular area |
| T2c: all-disease-encompassing in a >30-cm diameter circular area |
| T3: generalized skin involvement |
| T3a: multiple lesions involving 2 noncontiguous body regions |
| T3b: Multiple lesions involving ≥3 body regions |
| N: node |
| N0: no clinical or pathologic lymph node involvement |
| N1: involvement of 1 peripheral lymph node region† that drains an area of current or prior skin involvement |
| N2: involvement of ≥2 peripheral lymph node regions or involvement of any lymph node region that does not drain an area of current or prior skin involvement |
| N3: involvement of central lymph nodes |
| M: visceral |
| M0: no evidence of extracutaneous non–lymph node disease |
| M1: extracutaneous non–lymph node disease present |
| T: skin |
| T1: solitary skin involvement |
| T1a: solitary lesion <5-cm diameter |
| T1b: solitary >5-cm diameter |
| T2: regional skin involvement: multiple lesions limited to 1 body region or 2 contiguous body regions* |
| T2a: all-disease-encompassing in a <15-cm diameter circular area |
| T2b: all-disease-encompassing in a >15- and <30-cm diameter circular area |
| T2c: all-disease-encompassing in a >30-cm diameter circular area |
| T3: generalized skin involvement |
| T3a: multiple lesions involving 2 noncontiguous body regions |
| T3b: Multiple lesions involving ≥3 body regions |
| N: node |
| N0: no clinical or pathologic lymph node involvement |
| N1: involvement of 1 peripheral lymph node region† that drains an area of current or prior skin involvement |
| N2: involvement of ≥2 peripheral lymph node regions or involvement of any lymph node region that does not drain an area of current or prior skin involvement |
| N3: involvement of central lymph nodes |
| M: visceral |
| M0: no evidence of extracutaneous non–lymph node disease |
| M1: extracutaneous non–lymph node disease present |
Definition of body regions: Head and neck: inferior border, superior border of clavicles, T1 spinous process. Chest: superior border, superior border of clavicles; inferior border, inferior margin of rib cage; lateral borders, midaxillary lines, glenohumeral joints (inclusive of axillae). Abdomen/genital: superior border, inferior margin of rib cage; inferior border, inguinal folds, anterior perineum; lateral borders, midaxillary lines. Upper back: superior border, T1 spinous process; inferior border, inferior margin of rib cage; lateral borders, midaxillary lines. Lower back/buttocks: superior border, inferior margin of rib cage; inferior border, inferior gluteal fold, anterior perineum (inclusive of perineum); lateral borders, midaxillary lines. Each upper arm: superior borders, glenohumeral joints (exclusive of axillae); inferior borders, ulnar/radial-humeral (elbow) joint. Each lower arm/hand: superior borders, ulnar/radial-humeral (elbow) joint. Each upper leg (thigh): superior borders, inguinal folds, inferior gluteal folds; inferior borders, midpatellae, midpopliteal fossae. Each lower leg/foot: superior borders, midpatellae, midpopliteal fossae.
Definition of lymph node regions is consistent with the Ann Arbor system. Peripheral sites: antecubital, cervical, supraclavicular, axillary, inguinal-femoral, and popliteal. Central sites: mediastinal, pulmonary hilar, paraortic, iliac.