Risks of myocardial infarction and ischemic stroke before cancer diagnosis
| Period before cancer diagnosis, d . | Cancer patients . | Cancer-free controls . | . | . |
|---|---|---|---|---|
| Outcomes, no. (%) . | Outcomes, no. (%) . | OR (95% CI) . | P . | |
| Myocardial infarction | ||||
| 1-30 | 1408 (0.38) | 220 (0.06) | 6.43 (5.57-7.41) | <.001 |
| 31-60 | 340 (0.09) | 201 (0.05) | 1.69 (1.42-2.01) | <.001 |
| 61-90 | 274 (0.07) | 170 (0.05) | 1.61 (1.33-1.95) | <.001 |
| 91-120 | 241 (0.06) | 187 (0.05) | 1.29 (1.07-1.56) | .009 |
| 121-150 | 237 (0.06) | 192 (0.05) | 1.24 (1.02-1.50) | .03 |
| 151-180 | 222 (0.06) | 200 (0.0%) | 1.11 (0.92-1.34) | .28 |
| 181-210 | 170 (0.05) | 170 (0.05) | 1.00 (0.81-1.24) | 1.00 |
| 211-240 | 222 (0.06) | 167 (0.04) | 1.33 (1.09-1.63) | .005 |
| 241-270 | 185 (0.05) | 162 (0.04) | 1.14 (0.93-1.41) | .22 |
| 271-300 | 199 (0.05) | 171 (0.05) | 1.16 (0.95-1.43) | .15 |
| 301-330 | 196 (0.05) | 155 (0.04) | 1.27 (1.02-1.56) | .03 |
| 331-360 | 183 (0.05) | 176 (0.05) | 1.04 (0.85-1.28) | .71 |
| Ischemic stroke | ||||
| 1-30 | 979 (0.26) | 195 (0.05) | 5.04 (4.32-5.88) | <.001 |
| 31-60 | 307 (0.08) | 170 (0.05) | 1.81 (1.50-2.18) | <.001 |
| 61-90 | 232 (0.06) | 154 (0.04) | 1.51 (1.23-1.85) | <.001 |
| 91-120 | 195 (0.05) | 169 (0.05) | 1.15 (0.94-1.42) | .17 |
| 121-150 | 196 (0.05) | 153 (0.04) | 1.28 (1.04-1.58) | .02 |
| 151-180 | 168 (0.04) | 141 (0.04) | 1.19 (0.95-1.49) | .13 |
| 181-210 | 144 (0.04) | 122 (0.03) | 1.18 (0.93-1.50) | .18 |
| 211-240 | 156 (0.04) | 157 (0.04) | 0.99 (0.80-1.24) | .95 |
| 241-270 | 126 (0.03) | 144 (0.04) | 0.88 (0.69-1.11) | .27 |
| 271-300 | 128 (0.03) | 144 (0.04) | 0.89 (0.70-1.13) | .33 |
| 301-330 | 144 (0.04) | 162 (0.04) | 0.89 (0.71-1.11) | .30 |
| 331-360 | 138 (0.04) | 125 (0.03) | 1.10 (0.87-1.41) | .42 |
| Period before cancer diagnosis, d . | Cancer patients . | Cancer-free controls . | . | . |
|---|---|---|---|---|
| Outcomes, no. (%) . | Outcomes, no. (%) . | OR (95% CI) . | P . | |
| Myocardial infarction | ||||
| 1-30 | 1408 (0.38) | 220 (0.06) | 6.43 (5.57-7.41) | <.001 |
| 31-60 | 340 (0.09) | 201 (0.05) | 1.69 (1.42-2.01) | <.001 |
| 61-90 | 274 (0.07) | 170 (0.05) | 1.61 (1.33-1.95) | <.001 |
| 91-120 | 241 (0.06) | 187 (0.05) | 1.29 (1.07-1.56) | .009 |
| 121-150 | 237 (0.06) | 192 (0.05) | 1.24 (1.02-1.50) | .03 |
| 151-180 | 222 (0.06) | 200 (0.0%) | 1.11 (0.92-1.34) | .28 |
| 181-210 | 170 (0.05) | 170 (0.05) | 1.00 (0.81-1.24) | 1.00 |
| 211-240 | 222 (0.06) | 167 (0.04) | 1.33 (1.09-1.63) | .005 |
| 241-270 | 185 (0.05) | 162 (0.04) | 1.14 (0.93-1.41) | .22 |
| 271-300 | 199 (0.05) | 171 (0.05) | 1.16 (0.95-1.43) | .15 |
| 301-330 | 196 (0.05) | 155 (0.04) | 1.27 (1.02-1.56) | .03 |
| 331-360 | 183 (0.05) | 176 (0.05) | 1.04 (0.85-1.28) | .71 |
| Ischemic stroke | ||||
| 1-30 | 979 (0.26) | 195 (0.05) | 5.04 (4.32-5.88) | <.001 |
| 31-60 | 307 (0.08) | 170 (0.05) | 1.81 (1.50-2.18) | <.001 |
| 61-90 | 232 (0.06) | 154 (0.04) | 1.51 (1.23-1.85) | <.001 |
| 91-120 | 195 (0.05) | 169 (0.05) | 1.15 (0.94-1.42) | .17 |
| 121-150 | 196 (0.05) | 153 (0.04) | 1.28 (1.04-1.58) | .02 |
| 151-180 | 168 (0.04) | 141 (0.04) | 1.19 (0.95-1.49) | .13 |
| 181-210 | 144 (0.04) | 122 (0.03) | 1.18 (0.93-1.50) | .18 |
| 211-240 | 156 (0.04) | 157 (0.04) | 0.99 (0.80-1.24) | .95 |
| 241-270 | 126 (0.03) | 144 (0.04) | 0.88 (0.69-1.11) | .27 |
| 271-300 | 128 (0.03) | 144 (0.04) | 0.89 (0.70-1.13) | .33 |
| 301-330 | 144 (0.04) | 162 (0.04) | 0.89 (0.71-1.11) | .30 |
| 331-360 | 138 (0.04) | 125 (0.03) | 1.10 (0.87-1.41) | .42 |