Cox proportional hazards model for all SMNs, for patients who were alive 1 year posttransplant
| Risk factor . | HR . | 95% lower CI . | P . |
|---|---|---|---|
| Race | |||
| Other | 1.0 | Ref | Ref |
| White | 1.8 | (1.0, 2.9) | .04 |
| Sex | |||
| Female | 1.0 | Ref | Ref |
| Male | 0.9 | (0.7, 1.1) | .24 |
| Age at first allogeneic HCT | |||
| >50 y | 1.0 | Ref | Ref |
| >20-50 y | 1.2 | (0.97-1.8) | .24 |
| ≤20 y | 2.3 | (1.3, 4.0) | .003 |
| HCT diagnosis category | |||
| Nonmalignant diseases | 1.0 | Ref | Ref |
| Hematologic malignancies | 1.0 | (0.7, 1.6) | .90 |
| Stem cell source | |||
| BM | 1.0 | Ref | Ref |
| Cord | 3.0 | (1.3, 7.1) | .01 |
| PBSC ± BM | 1.6 | (1.2, 2.1) | .003 |
| Preparative regimen | |||
| Chemotherapy only | 1.0 | Ref | Ref |
| Low-dose TBI 200-450 cGy | 1.2 | (0.8, 1.7) | .42 |
| Single-fraction TBI 600-1000 cGy | 3.2 | (1.9, 5.3) | <.0001 |
| Fractionated TBI 600-1200 cGy | 1.7 | (1.3, 2.2) | .0004 |
| Fractionated TBI 1320-1400 cGy | 1.6 | (1.1, 2.2) | .02 |
| Fractionated TBI 1440-1750 cGy | 2.1 | (1.5, 3.1) | <.0001 |
| GVHD status | |||
| None | 1.0 | Ref | Ref |
| Acute only | 1.4 | (1.0, 1.9) | .05 |
| Chronic ± acute | 1.2 | (1.0, 1.6) | .10 |
| Risk factor . | HR . | 95% lower CI . | P . |
|---|---|---|---|
| Race | |||
| Other | 1.0 | Ref | Ref |
| White | 1.8 | (1.0, 2.9) | .04 |
| Sex | |||
| Female | 1.0 | Ref | Ref |
| Male | 0.9 | (0.7, 1.1) | .24 |
| Age at first allogeneic HCT | |||
| >50 y | 1.0 | Ref | Ref |
| >20-50 y | 1.2 | (0.97-1.8) | .24 |
| ≤20 y | 2.3 | (1.3, 4.0) | .003 |
| HCT diagnosis category | |||
| Nonmalignant diseases | 1.0 | Ref | Ref |
| Hematologic malignancies | 1.0 | (0.7, 1.6) | .90 |
| Stem cell source | |||
| BM | 1.0 | Ref | Ref |
| Cord | 3.0 | (1.3, 7.1) | .01 |
| PBSC ± BM | 1.6 | (1.2, 2.1) | .003 |
| Preparative regimen | |||
| Chemotherapy only | 1.0 | Ref | Ref |
| Low-dose TBI 200-450 cGy | 1.2 | (0.8, 1.7) | .42 |
| Single-fraction TBI 600-1000 cGy | 3.2 | (1.9, 5.3) | <.0001 |
| Fractionated TBI 600-1200 cGy | 1.7 | (1.3, 2.2) | .0004 |
| Fractionated TBI 1320-1400 cGy | 1.6 | (1.1, 2.2) | .02 |
| Fractionated TBI 1440-1750 cGy | 2.1 | (1.5, 3.1) | <.0001 |
| GVHD status | |||
| None | 1.0 | Ref | Ref |
| Acute only | 1.4 | (1.0, 1.9) | .05 |
| Chronic ± acute | 1.2 | (1.0, 1.6) | .10 |
HR, hazard ratio; ref, reference.