Patient characteristics
| . | All (N = 163) . | Active surveillance (n = 37) . | Any other treatment (n = 126) . | P . |
|---|---|---|---|---|
| Male | 103 (63) | 22 (60) | 81 (64) | .70 |
| Age at diagnosis, y | 40 (16-75) | 47 (20-75) | 39 (16-74) | .03 |
| Year of diagnosis | 2009 (1974-2016) | 2012 (1998-2016) | 2007 (1974-2016) | <.001 |
| Stage I/II | 121 (74) | 23 (62) | 98 (78) | .09 |
| Involved Ann Arbor regions | 2 (0-12) | 2 (0-7) | 2 (1-12) | .16 |
| B symptoms | 7 (4) | 0 (0) | 7 (6) | .35 |
| Extranodal disease | 11 (7) | 1 (3) | 10 (8) | .46 |
| Mediastinal involvement | 22 (14) | 5 (14) | 17 (14) | >.99 |
| Splenic involvement | 12 (7) | 0 (0) | 12 (10) | .07 |
| Bulky disease ≥5 cm | 21 (13) | 4 (11) | 17 (14) | .79 |
| Bulky disease ≥10 cm | 2 (1) | 0 (0) | 2 (2) | >.99 |
| Disease involvement | ||||
| Above diaphragm | 82 (50) | 14 (38) | 68 (54) | .12 |
| Below diaphragm | 39 (24) | 9 (24) | 30 (24) | |
| Both sides of diaphragm | 42 (26) | 14 (38) | 28 (22) | |
| Hemoglobin, g/dL (n = 137) | 14.4 (10.6-17.2) | 14.0 (11.6-15.8) | 14.5 (10.6-17.2) | .12 |
| WBC, 1000/μL (n = 138) | 6.4 (2.7-12.6) | 6.7 (2.7-11.4) | 6.4 (3.0-12.6) | .55 |
| LDH, U/L (n = 97) | 181 (101-323) | 175 (140-303) | 182 (101-323) | .81 |
| Albumin, g/dL (n = 126) | 4.5 (3.8-5.3) | 4.5 (3.8-5.0) | 4.6 (3.9-5.3) | .27 |
| Percentage of lymphocytes in differential count (n = 134) | 29 (15-57) | 29 (15-44) | 28 (9-57) | .67 |
| IPS (n = 125) | 1 (0-3) | 1 (0-3) | 1 (0-3) | .85 |
| R-IPI (n = 97) | 0 (0-2) | 0 (0-2) | 1 (0-2) | .45 |
| . | All (N = 163) . | Active surveillance (n = 37) . | Any other treatment (n = 126) . | P . |
|---|---|---|---|---|
| Male | 103 (63) | 22 (60) | 81 (64) | .70 |
| Age at diagnosis, y | 40 (16-75) | 47 (20-75) | 39 (16-74) | .03 |
| Year of diagnosis | 2009 (1974-2016) | 2012 (1998-2016) | 2007 (1974-2016) | <.001 |
| Stage I/II | 121 (74) | 23 (62) | 98 (78) | .09 |
| Involved Ann Arbor regions | 2 (0-12) | 2 (0-7) | 2 (1-12) | .16 |
| B symptoms | 7 (4) | 0 (0) | 7 (6) | .35 |
| Extranodal disease | 11 (7) | 1 (3) | 10 (8) | .46 |
| Mediastinal involvement | 22 (14) | 5 (14) | 17 (14) | >.99 |
| Splenic involvement | 12 (7) | 0 (0) | 12 (10) | .07 |
| Bulky disease ≥5 cm | 21 (13) | 4 (11) | 17 (14) | .79 |
| Bulky disease ≥10 cm | 2 (1) | 0 (0) | 2 (2) | >.99 |
| Disease involvement | ||||
| Above diaphragm | 82 (50) | 14 (38) | 68 (54) | .12 |
| Below diaphragm | 39 (24) | 9 (24) | 30 (24) | |
| Both sides of diaphragm | 42 (26) | 14 (38) | 28 (22) | |
| Hemoglobin, g/dL (n = 137) | 14.4 (10.6-17.2) | 14.0 (11.6-15.8) | 14.5 (10.6-17.2) | .12 |
| WBC, 1000/μL (n = 138) | 6.4 (2.7-12.6) | 6.7 (2.7-11.4) | 6.4 (3.0-12.6) | .55 |
| LDH, U/L (n = 97) | 181 (101-323) | 175 (140-303) | 182 (101-323) | .81 |
| Albumin, g/dL (n = 126) | 4.5 (3.8-5.3) | 4.5 (3.8-5.0) | 4.6 (3.9-5.3) | .27 |
| Percentage of lymphocytes in differential count (n = 134) | 29 (15-57) | 29 (15-44) | 28 (9-57) | .67 |
| IPS (n = 125) | 1 (0-3) | 1 (0-3) | 1 (0-3) | .85 |
| R-IPI (n = 97) | 0 (0-2) | 0 (0-2) | 1 (0-2) | .45 |
Data are presented as median (range) for continuous variables and as n (%) for count variables. If data were not available for all patients (N = 163), the number of patients with available data is shown in parentheses after the variable.
LDH, lactate dehydrogenase; WBC, white blood cell count.