Supportive clinical and laboratory features further differentiating TACO from TRALI
| Supportive clinical and laboratory features . | TACO . | TRALI . |
|---|---|---|
| Neck veins | Distended | Normal |
| Auscultation | Rales, S3 | Rales, No S3 |
| Blood pressure | Hypertension | Hypotension |
| Body temperature | Fever may be present (1/3 of patients)36 | Febrile |
| White blood cell count | Unknown | Transient leukopenia (infrequent) and mild thrombocytopenia37-40 |
| Leukocyte antibodies | Unknown | May be present (±80%)41 : |
| Anti-HLA class I antibodies | ||
| Anti-HLA class II antibodies | ||
| Anti-HNA antibodies | ||
| Posttransfusion cytokines49-51,59 | IL-6 increased | IL-6 increased |
| IL-8 not increased | IL-8 increased | |
| IL-10 increased | IL-10 not increased | |
| No changes in TNF-α, GM-CSF | No changes in TNF-α, GM-CSF |
| Supportive clinical and laboratory features . | TACO . | TRALI . |
|---|---|---|
| Neck veins | Distended | Normal |
| Auscultation | Rales, S3 | Rales, No S3 |
| Blood pressure | Hypertension | Hypotension |
| Body temperature | Fever may be present (1/3 of patients)36 | Febrile |
| White blood cell count | Unknown | Transient leukopenia (infrequent) and mild thrombocytopenia37-40 |
| Leukocyte antibodies | Unknown | May be present (±80%)41 : |
| Anti-HLA class I antibodies | ||
| Anti-HLA class II antibodies | ||
| Anti-HNA antibodies | ||
| Posttransfusion cytokines49-51,59 | IL-6 increased | IL-6 increased |
| IL-8 not increased | IL-8 increased | |
| IL-10 increased | IL-10 not increased | |
| No changes in TNF-α, GM-CSF | No changes in TNF-α, GM-CSF |
Modified from Skeate et al.35