Temporal relationship between transfusions and noninfectious adverse outcomes and their rate per components transfused based on National Blood Collection and Utilization Surveys, 2011 to 2015
| Name . | Temporal relationship to transfusion . | Severity . | Reaction rate in 2015* . | Reaction rate as range reported in 2011, 2013, and 2015* . |
|---|---|---|---|---|
| Allergic/urticarial | 0-4 h | Mild-moderate | 1:1 200 | 1:1 200-1:1 500 |
| Acute hemolytic (ABO related) | 0-24 h | Severe | 1:200 000 | 1:200 000-1:500 000 |
| Acute hemolytic (non-ABO related) | 0-24 h | Mild-severe | 1:105 000 | 1:105 000-1:125 000 |
| Anaphylactic | 0-1 h | Severe | 1:30 000 | 1:30 000-1:42 000 |
| Delayed serologic | 1-28 d | Mild | 1:5 400 | 1:5 400-1:8 200 |
| Delayed hemolytic | 1-28 d | Mild-moderate | 1:22 000 | 1:19 000-1:23 000 |
| Febrile nonhemolytic | 0-4 h | Mild | 1:900 | 1:800-1:1 000 |
| Hypotensive | 0-1 h | Mild-moderate | 1:11 000 | 1:11 000-1:18 000 |
| Posttransfusion purpura | 2-14 d | Severe | 1:57 000 | 1:57 000-1:100 000 |
| TACO | 0-6 h | Mild-severe | 1:9 000 | 1:9 000-1:13 000 |
| TRALI | 0-6 h | Mild-severe | 1:60 000 | 1:57 000-1:64 000 |
| Transfusion-associated dyspnea | 0-24 h | Mild | 1:14 000 | 1:14 000-1:23 000 |
| Transfusion-associated graft-versus-host disease | 4-30 d | Severe (often fatal) | 1:13 000 000 | 1:950 000-1:13 000 000 |
| Name . | Temporal relationship to transfusion . | Severity . | Reaction rate in 2015* . | Reaction rate as range reported in 2011, 2013, and 2015* . |
|---|---|---|---|---|
| Allergic/urticarial | 0-4 h | Mild-moderate | 1:1 200 | 1:1 200-1:1 500 |
| Acute hemolytic (ABO related) | 0-24 h | Severe | 1:200 000 | 1:200 000-1:500 000 |
| Acute hemolytic (non-ABO related) | 0-24 h | Mild-severe | 1:105 000 | 1:105 000-1:125 000 |
| Anaphylactic | 0-1 h | Severe | 1:30 000 | 1:30 000-1:42 000 |
| Delayed serologic | 1-28 d | Mild | 1:5 400 | 1:5 400-1:8 200 |
| Delayed hemolytic | 1-28 d | Mild-moderate | 1:22 000 | 1:19 000-1:23 000 |
| Febrile nonhemolytic | 0-4 h | Mild | 1:900 | 1:800-1:1 000 |
| Hypotensive | 0-1 h | Mild-moderate | 1:11 000 | 1:11 000-1:18 000 |
| Posttransfusion purpura | 2-14 d | Severe | 1:57 000 | 1:57 000-1:100 000 |
| TACO | 0-6 h | Mild-severe | 1:9 000 | 1:9 000-1:13 000 |
| TRALI | 0-6 h | Mild-severe | 1:60 000 | 1:57 000-1:64 000 |
| Transfusion-associated dyspnea | 0-24 h | Mild | 1:14 000 | 1:14 000-1:23 000 |
| Transfusion-associated graft-versus-host disease | 4-30 d | Severe (often fatal) | 1:13 000 000 | 1:950 000-1:13 000 000 |
Numbers are approximated to the nearest 100s, 1000s, 10 000s, and 100 000s.