Safety evaluation after single (rising) dose administrations of MAA868 in female cynomolgus monkeys
• No mortality occurred during the study |
• No drug-related effects on clinical signs, body weight, food consumption, ophthalmologic and electrocardiographic parameters, hematology, clinical chemistry, urinalysis |
• No macroscopic or microscopic indications of bleeding (including no bruising, no gum bleeds, and no extended bleeding at either SC or IV drug injection sites or blood sampling sites) |
• No occult blood detected (in feces) |
• No target organs of toxicity identified |
• No mortality occurred during the study |
• No drug-related effects on clinical signs, body weight, food consumption, ophthalmologic and electrocardiographic parameters, hematology, clinical chemistry, urinalysis |
• No macroscopic or microscopic indications of bleeding (including no bruising, no gum bleeds, and no extended bleeding at either SC or IV drug injection sites or blood sampling sites) |
• No occult blood detected (in feces) |
• No target organs of toxicity identified |