Table 3.

Safety evaluation after single (rising) dose administrations of MAA868 in female cynomolgus monkeys

• No mortality occurred during the study

 

• No drug-related effects on clinical signs, body weight, food consumption, ophthalmologic and electrocardiographic parameters, hematology, clinical chemistry, urinalysis

 

• No macroscopic or microscopic indications of bleeding (including no bruising, no gum bleeds, and no extended bleeding at either SC or IV drug injection sites or blood sampling sites)

 

• No occult blood detected (in feces)

 

• No target organs of toxicity identified

 

• No mortality occurred during the study

 

• No drug-related effects on clinical signs, body weight, food consumption, ophthalmologic and electrocardiographic parameters, hematology, clinical chemistry, urinalysis

 

• No macroscopic or microscopic indications of bleeding (including no bruising, no gum bleeds, and no extended bleeding at either SC or IV drug injection sites or blood sampling sites)

 

• No occult blood detected (in feces)

 

• No target organs of toxicity identified

 
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