Mean PK parameters after single (rising) dose administrations of MAA868 in female cynomolgus monkeys
| Dose (mg/kg) . | Route . | Tmax (h) . | Cmax (µg/mL) . | AUC0-14d (µg ∙ d/mL) . |
|---|---|---|---|---|
| 3 | IV | 0.25 | 96.0 | 544 |
| SC | 168 | 36.0 | 360 | |
| 10 | IV | 0.25 | 325 | 1810 |
| SC | 132 | 101 | 1160 | |
| 30 | IV | 1.08 | 1170 | 6770 |
| SC | 132 | 344 | 4140 |
| Dose (mg/kg) . | Route . | Tmax (h) . | Cmax (µg/mL) . | AUC0-14d (µg ∙ d/mL) . |
|---|---|---|---|---|
| 3 | IV | 0.25 | 96.0 | 544 |
| SC | 168 | 36.0 | 360 | |
| 10 | IV | 0.25 | 325 | 1810 |
| SC | 132 | 101 | 1160 | |
| 30 | IV | 1.08 | 1170 | 6770 |
| SC | 132 | 344 | 4140 |
Tmax, median time-to-peak MAA868 plasma concentrations.