Table 1.

Affinity (KD) of FXI antibodies determined by using solution equilibrium titration measurements

AntibodyAntigenKDn
NOV1090-Fab Human FXIa 244 ± 96 pM 3 
MAA868-IgG 4.7 ± 2.1 pM 3 
NOV1090-Fab Human FXI 163 ± 24 pM 3 
MAA868-IgG 1.3 ± 0.3 pM 3 
MAA868-IgG cyno FXIa 6-19 pM 2 
MAA868-IgG cyno FXI 4-6 pM 2 
AntibodyAntigenKDn
NOV1090-Fab Human FXIa 244 ± 96 pM 3 
MAA868-IgG 4.7 ± 2.1 pM 3 
NOV1090-Fab Human FXI 163 ± 24 pM 3 
MAA868-IgG 1.3 ± 0.3 pM 3 
MAA868-IgG cyno FXIa 6-19 pM 2 
MAA868-IgG cyno FXI 4-6 pM 2 

cyno, cynomolgus monkey.

View Large
Close Modal
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal