Unique and overlapping commonly used stem cell terms and definitions
| Term . | Widely accepted definition . |
|---|---|
| Long-term HSC | Cells able to reconstitute all 5 types of mature blood cells in recipient mice over the long term (≥16-wk after transplantation) and in secondary and tertiary transplants28 |
| Intermediate-term repopulating HSC | Cells that reconstitute multilineage blood cells over the medium term (6-8 mo), but show some loss of self-renewal in secondary transplant recipients28 |
| Short-term repopulating HSC | Cells that transiently reconstitute multiple blood cell types for up to 8 wk in transplant recipients, or in which 1 or more donor-derived lineages disappear before 24 wk after primary transplant |
| Lineage priming | Expression of a transcriptional program associated with potential for differentiation to mature cells of a specific lineage in a multi/oligopotent cell |
| Lineage bias | Multi-/oligopotent cells that preferentially give rise to a single lineage but retain potential for alternative differentiation |
| Lineage restricted/committed | Oligo-/unipotent cells not able to give rise to cells of certain lineages |
| Lineage potential | The mature lineages that a cell has the potential to give rise to, depending on external stimuli |
| Lineage fate | The lineage that a stem/progenitor will give rise to in vivo |
| Term . | Widely accepted definition . |
|---|---|
| Long-term HSC | Cells able to reconstitute all 5 types of mature blood cells in recipient mice over the long term (≥16-wk after transplantation) and in secondary and tertiary transplants28 |
| Intermediate-term repopulating HSC | Cells that reconstitute multilineage blood cells over the medium term (6-8 mo), but show some loss of self-renewal in secondary transplant recipients28 |
| Short-term repopulating HSC | Cells that transiently reconstitute multiple blood cell types for up to 8 wk in transplant recipients, or in which 1 or more donor-derived lineages disappear before 24 wk after primary transplant |
| Lineage priming | Expression of a transcriptional program associated with potential for differentiation to mature cells of a specific lineage in a multi/oligopotent cell |
| Lineage bias | Multi-/oligopotent cells that preferentially give rise to a single lineage but retain potential for alternative differentiation |
| Lineage restricted/committed | Oligo-/unipotent cells not able to give rise to cells of certain lineages |
| Lineage potential | The mature lineages that a cell has the potential to give rise to, depending on external stimuli |
| Lineage fate | The lineage that a stem/progenitor will give rise to in vivo |