Dosing nomogram for romiplostim
| Platelet count, × 109/L . | Action* . |
|---|---|
| <50 | Increase by 1 μg/kg |
| 50-200 | No change |
| >200 | If >200 × 109/L for 2 consecutive weeks, reduce dose by 1 μg/kg. |
| >400 | Do not give dose. Access weekly platelet count. Once platelet count is <200 × 109/L, resume at dose decreased by 1 μg/kg. |
| Platelet count, × 109/L . | Action* . |
|---|---|
| <50 | Increase by 1 μg/kg |
| 50-200 | No change |
| >200 | If >200 × 109/L for 2 consecutive weeks, reduce dose by 1 μg/kg. |
| >400 | Do not give dose. Access weekly platelet count. Once platelet count is <200 × 109/L, resume at dose decreased by 1 μg/kg. |
Begin at 1 μg/kg and increase to maximum dose of 10 μg/kg. If no response at 10 μg/kg for 4 weeks, discontinue romiplostim.