Table 1. Longitudinal T-LGLL... | American Society of Hematology

Table 1.

Longitudinal T-LGLL characteristics of patients with leukemia

	STAT3^MT	Hematologic presentation	AAD, y	Sex	Therapy	LGL count*	Flow cytometry		TCR deep sequencing
	STAT3^MT	Hematologic presentation	AAD, y	Sex	Therapy	LGL count*	VB ID	Clone size*, %	Major clonotype(s)	Clone size*, %	Clonal diversity*^,†	Clonality*^,†
CCF1	D661V	Anemia	68	M	CSA, CYC, MTX	2455	NIP	65	CASSLLAGGYNEQFF	42	0.176	0.373
CCF2	D661V	Neutropenia thrombocytopenia	81	M	MTX	1225	TRBV9	72	CASSVGQGSPLHF	75	0.565	0.734
CCF3	Y640F	Neutropenia thrombocytopenia	55	F	CSA	1355	TRBV6-2, TRBV3-1	25, 16	CASSLASISYNEQFF	26	0.068	0.263
CCF4	D661Y, Y640F	Pancytopenia	64	M	CSA, MTX	3672	TRBV10-3	23	CASSAPREGTAYEQYF, CASSPTSGGEQFF	8, 5	0.016	0.222
CCF5	D661Y	Anemia, neutropenia	54	M	CSA, CYC	10 631	TRBV9	99	CASSVGRFQETQYF	44	0.192	0.378
CCF6	Y640F	Neutropenia	47	M	CSA, CYC, MTX	850	TRBV29-1	8, 11	CASSTFAEIRQPQHF, CASSLTENYGYTF	4, 0.01	0.002	0.046
CCF7	D661Y	Neutropenia	40	M	CSA, CYC, MTX	2882	NIP	95	CATSRGTGDSYEQYF	97	0.934	0.938
CCF8	Y640F	Anemia, neutropenia	37	F	CSA	480	TRBV12-3, TRBV12-4	82	CASSSLTGLPPYEQYF	29	0.085	0.247
CCF9	Y640F	Anemia, neutropenia	74	F	CSA, CYC, MTX	496	NIP	96	CASSPEGFQPQHF, CASTSFGTGTDTQYF	91, 0.16	0.819	0.871
CCF10	Negative	Anemia, neutropenia	17	M	CSA, MTX	330	TRBV18	77	CASSPFWTLEKLFF	93	0.871	0.893
CCF11	Negative	Anemia	63	M	CSA, CYC, MTX	980	TRVB28, TRBV19	32, 18	CASSPLGAVGYNEQFF, CAISEFPGGQTSDEGFF	25, 1	0.086	0.471
CCF12	Negative	Neutropenia	47	F	CSA, MTX	188	TRBV12-3, TRBV12-4	45	CASSIAGLGSEQFF, CASSEGQMYNEQFF	12, 3	0.019	0.191
CCF13	Negative	Anemia, neutropenia	52	F	CSA, CYC, MTX	261	TRBV13	97	CASSDLAGMLGRQFF	99	0.983	0.984
CCF14	Negative	Anemia	66	M	CYC	409	NIP, TRBV20-1	84, 24	CASSLEIAGGLIYNEQFF, CASSPGLAGGRETQYF	27, 2	0.093	0.350
CCF15	Negative	Anemia, neutropenia	60	M	CSA, CYC, MDX	4472	TRBV19	97	CASSIGIQPQHF	83	0.686	0.791
CCF16	Negative	Asymptomatic	59	M	SCT, CYC	1515	TRBV27	30	CASSSVGYEQYF	40	0.173	0.478
CCF17	Negative	Anemia	71	F	MTX	2536	TRBV19	20	CASRASGSDEQYF, CARSRDKGTDYGYTF	10, 8	0.024	0.263
CCF18	Negative	Asymptomatic	54	M	None	686	TRBV27, TRVB4-3	12, 8	CASSLGNYEQYF, CASSISQNTEAFF	4, 7	0.026	0.319

	STAT3^MT	Hematologic presentation	AAD, y	Sex	Therapy	LGL count*	Flow cytometry		TCR deep sequencing
	STAT3^MT	Hematologic presentation	AAD, y	Sex	Therapy	LGL count*	VB ID	Clone size*, %	Major clonotype(s)	Clone size*, %	Clonal diversity*^,†	Clonality*^,†
CCF1	D661V	Anemia	68	M	CSA, CYC, MTX	2455	NIP	65	CASSLLAGGYNEQFF	42	0.176	0.373
CCF2	D661V	Neutropenia thrombocytopenia	81	M	MTX	1225	TRBV9	72	CASSVGQGSPLHF	75	0.565	0.734
CCF3	Y640F	Neutropenia thrombocytopenia	55	F	CSA	1355	TRBV6-2, TRBV3-1	25, 16	CASSLASISYNEQFF	26	0.068	0.263
CCF4	D661Y, Y640F	Pancytopenia	64	M	CSA, MTX	3672	TRBV10-3	23	CASSAPREGTAYEQYF, CASSPTSGGEQFF	8, 5	0.016	0.222
CCF5	D661Y	Anemia, neutropenia	54	M	CSA, CYC	10 631	TRBV9	99	CASSVGRFQETQYF	44	0.192	0.378
CCF6	Y640F	Neutropenia	47	M	CSA, CYC, MTX	850	TRBV29-1	8, 11	CASSTFAEIRQPQHF, CASSLTENYGYTF	4, 0.01	0.002	0.046
CCF7	D661Y	Neutropenia	40	M	CSA, CYC, MTX	2882	NIP	95	CATSRGTGDSYEQYF	97	0.934	0.938
CCF8	Y640F	Anemia, neutropenia	37	F	CSA	480	TRBV12-3, TRBV12-4	82	CASSSLTGLPPYEQYF	29	0.085	0.247
CCF9	Y640F	Anemia, neutropenia	74	F	CSA, CYC, MTX	496	NIP	96	CASSPEGFQPQHF, CASTSFGTGTDTQYF	91, 0.16	0.819	0.871
CCF10	Negative	Anemia, neutropenia	17	M	CSA, MTX	330	TRBV18	77	CASSPFWTLEKLFF	93	0.871	0.893
CCF11	Negative	Anemia	63	M	CSA, CYC, MTX	980	TRVB28, TRBV19	32, 18	CASSPLGAVGYNEQFF, CAISEFPGGQTSDEGFF	25, 1	0.086	0.471
CCF12	Negative	Neutropenia	47	F	CSA, MTX	188	TRBV12-3, TRBV12-4	45	CASSIAGLGSEQFF, CASSEGQMYNEQFF	12, 3	0.019	0.191
CCF13	Negative	Anemia, neutropenia	52	F	CSA, CYC, MTX	261	TRBV13	97	CASSDLAGMLGRQFF	99	0.983	0.984
CCF14	Negative	Anemia	66	M	CYC	409	NIP, TRBV20-1	84, 24	CASSLEIAGGLIYNEQFF, CASSPGLAGGRETQYF	27, 2	0.093	0.350
CCF15	Negative	Anemia, neutropenia	60	M	CSA, CYC, MDX	4472	TRBV19	97	CASSIGIQPQHF	83	0.686	0.791
CCF16	Negative	Asymptomatic	59	M	SCT, CYC	1515	TRBV27	30	CASSSVGYEQYF	40	0.173	0.478
CCF17	Negative	Anemia	71	F	MTX	2536	TRBV19	20	CASRASGSDEQYF, CARSRDKGTDYGYTF	10, 8	0.024	0.263
CCF18	Negative	Asymptomatic	54	M	None	686	TRBV27, TRVB4-3	12, 8	CASSLGNYEQYF, CASSISQNTEAFF	4, 7	0.026	0.319

AAD, age at diagnosis; CSA, cyclosporine-A; CYC, cyclophosphamide; F, female; FU, follow-up; M, male; MTX, methotrexate; SCT, stem cell transplant.

*At earliest sampling.

†Clonal diversity and Clonality assessed according to Clemente et al.⁹

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