Association between ABO blood group and FVIII PK parameters or plasma VWF properties
| . | Type O (n = 18), median (range) . | Non-O (n = 25), median (range) . | P . | Regression analysis β (CI); P . |
|---|---|---|---|---|
| FVIII PK | ||||
| Cl, mL/h | 173 (74-322) | 141 (47-400) | .136 | −34.84 (−74.25 to 4.57); .082 |
| k, h−1 | 0.072 (0.052-0.098) | 0.061 (0.038-0.130) | .007 | −0.011 (−0.021 to 0); .048 |
| Half-life, h | 9.62 (7.09-13.20) | 11.36 (5.32-18.43) | .007 | 2.231 (0.604 to 3.858); .008 |
| AUC, h·mIU/dL | 125.19 (83.42-176.39) | 150.86 (62.39-291.99) | .056 | 32.93 (2.30 to 63.56); .036 |
| VWF | ||||
| VWF:Ag, % | 86.84 (48.22-113.78) | 86.63 (39.94-141.64) | .3 | 13.2 (−5.348 to 31.75); .157 |
| VWFpp/VWF:Ag | 1.13 (0.84-1.70) | 0.963 (0.329-1.701) | .016 | −0.209 (−0.407 to −0.011); .039 |
| VWF:FVIIIB, % | 80.0 (27.0-291.5) | 82.9 (11.30-260.6) | .36 | 0.009 (−0.332 to 0.352); .955 |
| . | Type O (n = 18), median (range) . | Non-O (n = 25), median (range) . | P . | Regression analysis β (CI); P . |
|---|---|---|---|---|
| FVIII PK | ||||
| Cl, mL/h | 173 (74-322) | 141 (47-400) | .136 | −34.84 (−74.25 to 4.57); .082 |
| k, h−1 | 0.072 (0.052-0.098) | 0.061 (0.038-0.130) | .007 | −0.011 (−0.021 to 0); .048 |
| Half-life, h | 9.62 (7.09-13.20) | 11.36 (5.32-18.43) | .007 | 2.231 (0.604 to 3.858); .008 |
| AUC, h·mIU/dL | 125.19 (83.42-176.39) | 150.86 (62.39-291.99) | .056 | 32.93 (2.30 to 63.56); .036 |
| VWF | ||||
| VWF:Ag, % | 86.84 (48.22-113.78) | 86.63 (39.94-141.64) | .3 | 13.2 (−5.348 to 31.75); .157 |
| VWFpp/VWF:Ag | 1.13 (0.84-1.70) | 0.963 (0.329-1.701) | .016 | −0.209 (−0.407 to −0.011); .039 |
| VWF:FVIIIB, % | 80.0 (27.0-291.5) | 82.9 (11.30-260.6) | .36 | 0.009 (−0.332 to 0.352); .955 |
Bold results are statistically significant. Statistical significance was assessed using the Mann-Whitney U test and confirmed by regression analysis.
β, β coefficient; CI, confidence interval.