Association between FVIII PK profile and study subject physical characteristics and plasma VWF properties
| . | Cl, mL/h . | k, h−1 . | Half-life, h . | AUC, h·mIU/mL . |
|---|---|---|---|---|
| Age, y | r = 0.534 | r = −0.039 | r = 0.005 | r = 0.202 |
| P = .002 | P = .8027 | P = .9738 | P = .1939 | |
| BMI, kg/m2 | r = 0.512 | r = −0.008 | r = 0.0213 | r = 0.118 |
| P = .0005 | P = .9580 | P = .8941 | P = .0258 | |
| VWF:Ag, % | r = −0.615 | r = −0.741 | r = 0.777 | r = 0.656 |
| P < .0001 | P < .0001 | P < .0001 | P < .0001 | |
| VWFpp, % | r = −.0657 | r = −0.277 | r = 0.2112 | r = 0.036 |
| P = .6949 | P = .0922 | P = .202 | P = .8288 | |
| VWFpp/VWF:Ag | r = 0.634 | r = 0.538 | r = −0.598 | r = −0.644 |
| P < .0001 | P = .0005 | P < .0001 | P < .0001 | |
| VWF:FVIIIB, % | r = −0.510 | r = −0.499 | r = 0.484 | r = 0.317 |
| P = .006 | P = .0008 | P = .0012 | P = .0408 |
| . | Cl, mL/h . | k, h−1 . | Half-life, h . | AUC, h·mIU/mL . |
|---|---|---|---|---|
| Age, y | r = 0.534 | r = −0.039 | r = 0.005 | r = 0.202 |
| P = .002 | P = .8027 | P = .9738 | P = .1939 | |
| BMI, kg/m2 | r = 0.512 | r = −0.008 | r = 0.0213 | r = 0.118 |
| P = .0005 | P = .9580 | P = .8941 | P = .0258 | |
| VWF:Ag, % | r = −0.615 | r = −0.741 | r = 0.777 | r = 0.656 |
| P < .0001 | P < .0001 | P < .0001 | P < .0001 | |
| VWFpp, % | r = −.0657 | r = −0.277 | r = 0.2112 | r = 0.036 |
| P = .6949 | P = .0922 | P = .202 | P = .8288 | |
| VWFpp/VWF:Ag | r = 0.634 | r = 0.538 | r = −0.598 | r = −0.644 |
| P < .0001 | P = .0005 | P < .0001 | P < .0001 | |
| VWF:FVIIIB, % | r = −0.510 | r = −0.499 | r = 0.484 | r = 0.317 |
| P = .006 | P = .0008 | P = .0012 | P = .0408 |
The P values were determined using a 2-tailed test of significance. Bold results are statistically significant.
r, Pearson’s correlation.