Summary of study subject characteristics, FVIII PK profile, and plasma VWF properties
| . | Median . | Range . |
|---|---|---|
| Patient traits | ||
| Age, y | 10.6 | 6.0-17.7 |
| Weight, kg | 40.6 | 17.6-132.5 |
| Height, cm | 143.0 | 109.6-177.2 |
| BMI, kg/m2 | 19.3 | 14.4-42.8 |
| BSA, m2 | 1.3 | 0.7-2.4 |
| FVIII PK | ||
| Cl, mL/h | 149 | 47-400 |
| Vd, L | 2.12 | 1.20-4.29 |
| k, h−1 | 0.067 | 0.038-0.130 |
| Half-life, h | 10.38 | 5.32-18.43 |
| AUC, h·mIU/dL | 137.36 | 62.39-291.99 |
| Recovery, (IU/dL)/(IU/kg) | 2.18 | 1.3-5.14 |
| VWF | ||
| VWF:Ag, % | 86.74 | 39.94-141.64 |
| VWFpp, % | 85.84 | 43.46-156.63 |
| VWFpp/VWF:Ag | 1.09 | 0.33-1.71 |
| VWF:FVIIIB, % | 80.70 | 11.30-292.15 |
| . | Median . | Range . |
|---|---|---|
| Patient traits | ||
| Age, y | 10.6 | 6.0-17.7 |
| Weight, kg | 40.6 | 17.6-132.5 |
| Height, cm | 143.0 | 109.6-177.2 |
| BMI, kg/m2 | 19.3 | 14.4-42.8 |
| BSA, m2 | 1.3 | 0.7-2.4 |
| FVIII PK | ||
| Cl, mL/h | 149 | 47-400 |
| Vd, L | 2.12 | 1.20-4.29 |
| k, h−1 | 0.067 | 0.038-0.130 |
| Half-life, h | 10.38 | 5.32-18.43 |
| AUC, h·mIU/dL | 137.36 | 62.39-291.99 |
| Recovery, (IU/dL)/(IU/kg) | 2.18 | 1.3-5.14 |
| VWF | ||
| VWF:Ag, % | 86.74 | 39.94-141.64 |
| VWFpp, % | 85.84 | 43.46-156.63 |
| VWFpp/VWF:Ag | 1.09 | 0.33-1.71 |
| VWF:FVIIIB, % | 80.70 | 11.30-292.15 |
AUC, area under the curve; BMI, body mass index; BSA, body surface area; Cl, clearance; k, elimination rate constant; Vd, volume of distribution.