All grade IRRs
| IRRs, n (%) . | 1200 mg (n = 8) . | 1800 mg (n = 45) . |
|---|---|---|
| Chills | 1 (12.5) | 4 (8.9) |
| Pyrexia | 0 | 3 (6.7) |
| Hypotension | 0 | 2 (4.4) |
| Pruritus | 0 | 2 (4.4) |
| Paresthesia | 0 | 2 (4.4) |
| Noncardiac chest pain | 1 (12.5) | 0 |
| Dyspnea* | 1 (12.5) | 0 |
| Oropharyngeal pain | 0 | 1 (2.2) |
| Pharyngeal paresthesia | 0 | 1 (2.2) |
| Sinus pain | 0 | 1 (2.2) |
| Throat irritation | 0 | 1 (2.2) |
| Wheezing | 0 | 1 (2.2) |
| Hypertension* | 0 | 1 (2.2) |
| Flushing | 0 | 1 (2.2) |
| Nausea | 0 | 1 (2.2) |
| Tongue edema | 0 | 1 (2.2) |
| Vomiting | 0 | 1 (2.2) |
| Cold sweat | 0 | 1 (2.2) |
| Hyperhidrosis | 0 | 1 (2.2) |
| Rash | 0 | 1 (2.2) |
| IRRs, n (%) . | 1200 mg (n = 8) . | 1800 mg (n = 45) . |
|---|---|---|
| Chills | 1 (12.5) | 4 (8.9) |
| Pyrexia | 0 | 3 (6.7) |
| Hypotension | 0 | 2 (4.4) |
| Pruritus | 0 | 2 (4.4) |
| Paresthesia | 0 | 2 (4.4) |
| Noncardiac chest pain | 1 (12.5) | 0 |
| Dyspnea* | 1 (12.5) | 0 |
| Oropharyngeal pain | 0 | 1 (2.2) |
| Pharyngeal paresthesia | 0 | 1 (2.2) |
| Sinus pain | 0 | 1 (2.2) |
| Throat irritation | 0 | 1 (2.2) |
| Wheezing | 0 | 1 (2.2) |
| Hypertension* | 0 | 1 (2.2) |
| Flushing | 0 | 1 (2.2) |
| Nausea | 0 | 1 (2.2) |
| Tongue edema | 0 | 1 (2.2) |
| Vomiting | 0 | 1 (2.2) |
| Cold sweat | 0 | 1 (2.2) |
| Hyperhidrosis | 0 | 1 (2.2) |
| Rash | 0 | 1 (2.2) |
Grade 3 IRR; all other IRRs were grades 1 to 2.