Table 2. Maximum daratumumab C trough... | American Society of Hematology

Table 2.

Maximum daratumumab C_trough for DARA-MD 1200 mg, DARA-MD 1800 mg, and historical data for daratumumab 16 mg/kg IV

Variable	Dose and route of administration	No. of patients	Mean daratumumab C_trough on cycle 3 day 1, µg/mL	CV, %
DARA-MD (PAVO)	1200 mg SC	5	543.90	44
DARA-MD (PAVO)	1800 mg SC	42	744.20	52
Daratumumab (GEN501)²	16 mg/kg IV	27	617.17	51
Daratumumab (SIRIUS)¹⁶	16 mg/kg IV	73	573.49	58

Variable	Dose and route of administration	No. of patients	Mean daratumumab C_trough on cycle 3 day 1, µg/mL	CV, %
DARA-MD (PAVO)	1200 mg SC	5	543.90	44
DARA-MD (PAVO)	1800 mg SC	42	744.20	52
Daratumumab (GEN501)²	16 mg/kg IV	27	617.17	51
Daratumumab (SIRIUS)¹⁶	16 mg/kg IV	73	573.49	58

CV, coefficient of variation; SC, subcutaneously.