Basic characteristics and blood tests according to mutation type
| . | JAK2 V617F (A) . | CALR (B) . | P (A vs B) . | Nonmutated (C) . | P (A vs C) . | P (B vs C) . |
|---|---|---|---|---|---|---|
| Number | 613 | 32 | — | 19 313 | — | — |
| Sex, female/male, n (%) | 281/332 (46/54) | 11/21 (34/66) | .2 | 10 566/8747 (55/45) | <.0001 | .03 |
| Age, y | 60 (0.52) | 64 (2.3) | .1 | 56 (0.098) | <.0001 | .002 |
| Allele burden, % | 2.1 (0.34) | 7.5 (2.2) | <.0001 | — | — | — |
| Blood test results | ||||||
| Hemoglobin, g/dL | 14.2 (0.053) | 14.2 (0.24) | .8 | 14.0 (0.0089) | 0.04 | 1.0 |
| Hematocrit | 0.43 (0.0015) | 0.44 (0.0062) | .7 | 0.43 (0.00024) | .002 | .8 |
| Leukocytes, ×109/L | 7.7 (0.095) | 7.5 (0.41) | .6 | 7.3 (0.014) | <.0001 | .4 |
| Neutrophils, ×109/L | 4.4 (0.068) | 4.5 (0.21) | .7 | 4.1 (0.0096) | <.0001 | .1 |
| Thrombocytes, ×109/L | 280 (3.7) | 346 (37) | .01 | 250 (0.41) | <.0001 | <.0001 |
| Ferritin, µg/L | 150 (4.6) | 196 (31) | .4 | 158 (1.2) | <.0001 | .7 |
| hsCRP, mg/L | 2.3 (0.12) | 2.5 (0.63) | .7 | 2.8 (0.039) | .001 | .7 |
| Cholesterol, mmol/L | 5.4 (0.043) | 5.5 (0.20) | .5 | 5.5 (0.0076) | .006 | 1.0 |
| Alkaline phosphatase, U/L | 69 (0.83) | 66 (2.9) | 0.3 | 68 (0.14) | .6 | .4 |
| eGFR, mL/min/1.73 m2 | 81 (0.67) | 75 (3.2) | .03 | 82 (0.12) | .1 | .01 |
| . | JAK2 V617F (A) . | CALR (B) . | P (A vs B) . | Nonmutated (C) . | P (A vs C) . | P (B vs C) . |
|---|---|---|---|---|---|---|
| Number | 613 | 32 | — | 19 313 | — | — |
| Sex, female/male, n (%) | 281/332 (46/54) | 11/21 (34/66) | .2 | 10 566/8747 (55/45) | <.0001 | .03 |
| Age, y | 60 (0.52) | 64 (2.3) | .1 | 56 (0.098) | <.0001 | .002 |
| Allele burden, % | 2.1 (0.34) | 7.5 (2.2) | <.0001 | — | — | — |
| Blood test results | ||||||
| Hemoglobin, g/dL | 14.2 (0.053) | 14.2 (0.24) | .8 | 14.0 (0.0089) | 0.04 | 1.0 |
| Hematocrit | 0.43 (0.0015) | 0.44 (0.0062) | .7 | 0.43 (0.00024) | .002 | .8 |
| Leukocytes, ×109/L | 7.7 (0.095) | 7.5 (0.41) | .6 | 7.3 (0.014) | <.0001 | .4 |
| Neutrophils, ×109/L | 4.4 (0.068) | 4.5 (0.21) | .7 | 4.1 (0.0096) | <.0001 | .1 |
| Thrombocytes, ×109/L | 280 (3.7) | 346 (37) | .01 | 250 (0.41) | <.0001 | <.0001 |
| Ferritin, µg/L | 150 (4.6) | 196 (31) | .4 | 158 (1.2) | <.0001 | .7 |
| hsCRP, mg/L | 2.3 (0.12) | 2.5 (0.63) | .7 | 2.8 (0.039) | .001 | .7 |
| Cholesterol, mmol/L | 5.4 (0.043) | 5.5 (0.20) | .5 | 5.5 (0.0076) | .006 | 1.0 |
| Alkaline phosphatase, U/L | 69 (0.83) | 66 (2.9) | 0.3 | 68 (0.14) | .6 | .4 |
| eGFR, mL/min/1.73 m2 | 81 (0.67) | 75 (3.2) | .03 | 82 (0.12) | .1 | .01 |
Data are shown as raw mean (SE) for continuous variables. P values in bold are <.05