Logistic multiple regression analysis of CR/CRu at week 23 and Cox proportional hazard model for PFS
| Effect . | Logistic regression analysis of CR/CRu at week 23 . | Cox proportional hazards model for PFS . | ||||
|---|---|---|---|---|---|---|
| P . | OR . | 95% CI . | P . | HR . | 95% CI . | |
| Treatment, RL vs R | .1094* | 1.772 | 0.880-3.570 | .0413 | 0.611 | 0.380-0.981 |
| Grade, 3A vs 1 or 2 | .5797 | 1.296 | 0.518-3.244 | .9351 | 0.973 | 0.506-1.872 |
| Bulky disease, yes vs no | .2672 | 0.663 | 0.321-1.370 | .9262 | 0.977 | 0.601-1.588 |
| Risk by FLIPI score, high vs low or intermediate | .9979 | 0.999 | 0.497-2.008 | .0113 | 1.845 | 1.148-2.962 |
| Effect . | Logistic regression analysis of CR/CRu at week 23 . | Cox proportional hazards model for PFS . | ||||
|---|---|---|---|---|---|---|
| P . | OR . | 95% CI . | P . | HR . | 95% CI . | |
| Treatment, RL vs R | .1094* | 1.772 | 0.880-3.570 | .0413 | 0.611 | 0.380-0.981 |
| Grade, 3A vs 1 or 2 | .5797 | 1.296 | 0.518-3.244 | .9351 | 0.973 | 0.506-1.872 |
| Bulky disease, yes vs no | .2672 | 0.663 | 0.321-1.370 | .9262 | 0.977 | 0.601-1.588 |
| Risk by FLIPI score, high vs low or intermediate | .9979 | 0.999 | 0.497-2.008 | .0113 | 1.845 | 1.148-2.962 |
P value corresponding to a 2-sided test has to be divided by 2 for a 1-sided test (.0547) and is statistically significant according to the predefined 1-sided type 1 error of 0.10 for the primary end point of CR/CRu at week 23.