Table 1. IHC score (H score) of PD-L1,... | American Society of Hematology

Table 1.

IHC score (H score) of PD-L1, IRF4 and CD30 in primary ALK⁺ ALCL cases

ALCL	Sex	Age, yr	PD-L1				IRF4				CD30
ALCL	Sex	Age, yr	Intensity	Percentage	Percentage stage	H score: intensity × percentage stage	Intensity	Percentage	Percentage stage	H score: intensity × percentage stage	Intensity	Percentage	Percentage stage	H score: intensity × percentage stage
ALK⁺	Male	38	3	80%	4	12	2	85%	4	8	2	60%	3	6
ALK⁺	Male	17	3	90%	4	12	2	70%	3	6	3	80%	4	12
ALK⁺	Female	7	3	85%	4	12	2	30%	2	4	3	100%	4	12
ALK⁺	Male	23	3	95%	4	12	2	35%	2	4	3	90%	4	12
ALK⁺	Male	33	2	95%	4	8	2	50%	3	6	3	100%	4	12
ALK⁺	Female	21	2	90%	4	8	2	5%	1	2	2	40%	2	4
ALK⁺	Male	20	2	85%	4	8	1	25%	2	2	3	90%	4	12
ALK⁺	Female	10	2	60%	3	6	2	50%	3	6	3	80%	4	12
ALK⁺	Female	30	2	75%	3	6	2	50%	3	6	3	80%	4	12
ALK⁺	Male	58	2	50%	2	4	1	60%	3	3	3	100%	4	12
ALK⁺	Female	14	2	15%	1	2	0	0	0	0	2	40%	2	4
ALK⁺	Male	27	0	0	0	0	0	0	0	0	2	20%	2	4
ALK⁺	Female	39	0	0	0	0	2	5%	1	2	2	10%	1	2
ALK⁺	Female	39	0	0	0	0	2	10%	1	2	3	80%	4	12

ALCL	Sex	Age, yr	PD-L1				IRF4				CD30
ALCL	Sex	Age, yr	Intensity	Percentage	Percentage stage	H score: intensity × percentage stage	Intensity	Percentage	Percentage stage	H score: intensity × percentage stage	Intensity	Percentage	Percentage stage	H score: intensity × percentage stage
ALK⁺	Male	38	3	80%	4	12	2	85%	4	8	2	60%	3	6
ALK⁺	Male	17	3	90%	4	12	2	70%	3	6	3	80%	4	12
ALK⁺	Female	7	3	85%	4	12	2	30%	2	4	3	100%	4	12
ALK⁺	Male	23	3	95%	4	12	2	35%	2	4	3	90%	4	12
ALK⁺	Male	33	2	95%	4	8	2	50%	3	6	3	100%	4	12
ALK⁺	Female	21	2	90%	4	8	2	5%	1	2	2	40%	2	4
ALK⁺	Male	20	2	85%	4	8	1	25%	2	2	3	90%	4	12
ALK⁺	Female	10	2	60%	3	6	2	50%	3	6	3	80%	4	12
ALK⁺	Female	30	2	75%	3	6	2	50%	3	6	3	80%	4	12
ALK⁺	Male	58	2	50%	2	4	1	60%	3	3	3	100%	4	12
ALK⁺	Female	14	2	15%	1	2	0	0	0	0	2	40%	2	4
ALK⁺	Male	27	0	0	0	0	0	0	0	0	2	20%	2	4
ALK⁺	Female	39	0	0	0	0	2	5%	1	2	2	10%	1	2
ALK⁺	Female	39	0	0	0	0	2	10%	1	2	3	80%	4	12

Intensity of staining was evaluated according to the following scale: 0, no staining; 1, weak staining; 2, moderate staining; and 3, strong staining. The percentage score was determined according to the proportion of tumor cells found to express PD-L1. IRF4, or CD30 (percentage stage: 0%, 0; <20%, 1; >20% to <50%, 2; >50% to <75%, 3; >75%, 4) and then multiplied by the staining intensity score to obtain a final semiquantitative H score.

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