Table 1.

Characteristics of PNH patients

PatientSexSampling time pointAge at sampling, yTime after diagnosis, yWBC, ×109/LHb, g/dLPlatelets, ×109/LLDH, IU/L*Treatment at sampling
PNH01 Female First 44 20 2.4 9.3 101 274 Eculizumab 
  Second 46 22 5.3 9.6 142 192 Eculizumab 
PNH02 Female First 54 28 3.8 11.9 194 195 Eculizumab 
  Second 57 31 3.3 11.5 119 205 Eculizumab 
PNH03 Female First 83 15 1.6 10.4 107 208 Eculizumab 
  Second§ 86 18 1.5 9.8 111 215 Eculizumab 
PNH04 Female First 63 6.3 7.1 41 168 Cyclosporin A; eculizumab 
PNH05 Female First 49 3.7 6.8 180 1898 Metenolone; RBC transfusion 
PNH06 Female First 28 5.5 10.6 191 670 Cyclosporin A 
PatientSexSampling time pointAge at sampling, yTime after diagnosis, yWBC, ×109/LHb, g/dLPlatelets, ×109/LLDH, IU/L*Treatment at sampling
PNH01 Female First 44 20 2.4 9.3 101 274 Eculizumab 
  Second 46 22 5.3 9.6 142 192 Eculizumab 
PNH02 Female First 54 28 3.8 11.9 194 195 Eculizumab 
  Second 57 31 3.3 11.5 119 205 Eculizumab 
PNH03 Female First 83 15 1.6 10.4 107 208 Eculizumab 
  Second§ 86 18 1.5 9.8 111 215 Eculizumab 
PNH04 Female First 63 6.3 7.1 41 168 Cyclosporin A; eculizumab 
PNH05 Female First 49 3.7 6.8 180 1898 Metenolone; RBC transfusion 
PNH06 Female First 28 5.5 10.6 191 670 Cyclosporin A 

Hb, hemoglobin; LDH, lactate dehydrogenase; RBC, red blood cell; WBC, white blood cell.

*

Normal range, 110 to 225 IU/L.

After 24 months from first sampling.

After 29 months from first sampling.

§

After 35 months from first sampling.

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