Initial and follow-up evaluations
| Evaluations at diagnosis . | Evaluations at follow-up visits . |
|---|---|
| Complete blood count (including differentials) and comprehensive metabolic profile | Complete blood count (including differentials) and comprehensive metabolic profile |
| Spleen and liver size (should be measured as below costal margin) | Spleen and liver size (should be measured as below costal margin) |
| Bone marrow aspirate and biopsy (differentials and karyotype) | Bone marrow every 6 mo until complete cytogenetic response |
| Baseline molecular genetics (qRT-PCR for BCR-ABL1) with transcript type (eg, e14a2) | Molecular monitoring from peripheral blood by qRT-PCR (monthly in the first 3 mo, every 3 mo thereafter) |
| Categorize stage of disease (CML-CP, CML-AP, CML-BP), identify additional risk factors (eg, additional chromosomal aberrations) | Classify response according to treatment time as recommended by the ELN44 or NCCN42 (Table 3) In advanced phases of CML, also monitor bone marrow cytogenetics to detect clonal evolution |
| Evaluations at diagnosis . | Evaluations at follow-up visits . |
|---|---|
| Complete blood count (including differentials) and comprehensive metabolic profile | Complete blood count (including differentials) and comprehensive metabolic profile |
| Spleen and liver size (should be measured as below costal margin) | Spleen and liver size (should be measured as below costal margin) |
| Bone marrow aspirate and biopsy (differentials and karyotype) | Bone marrow every 6 mo until complete cytogenetic response |
| Baseline molecular genetics (qRT-PCR for BCR-ABL1) with transcript type (eg, e14a2) | Molecular monitoring from peripheral blood by qRT-PCR (monthly in the first 3 mo, every 3 mo thereafter) |
| Categorize stage of disease (CML-CP, CML-AP, CML-BP), identify additional risk factors (eg, additional chromosomal aberrations) | Classify response according to treatment time as recommended by the ELN44 or NCCN42 (Table 3) In advanced phases of CML, also monitor bone marrow cytogenetics to detect clonal evolution |
qRT, quantitative reverse transcription.