Levels of PGE2-G, 2-AG, and PGE2 in DRG of mice
| Lipid . | HbAA-BERK, n = 8 . | HbSS-BERK, n = 8 . | HbSS + R-flurbiprofen, n = 6 . |
|---|---|---|---|
| PGE2-G, fmol | 90 ± 12 | 592 ± 110* | 86 ± 17† |
| 2-AG, pmol | 569 ± 46 | 274 ± 35* | 873 ± 180† |
| PGE2, pmol | 1.8 ± 0.3 | 11.1 ± 1.3* | 9.5 ± 1.2‡ |
| Lipid . | HbAA-BERK, n = 8 . | HbSS-BERK, n = 8 . | HbSS + R-flurbiprofen, n = 6 . |
|---|---|---|---|
| PGE2-G, fmol | 90 ± 12 | 592 ± 110* | 86 ± 17† |
| 2-AG, pmol | 569 ± 46 | 274 ± 35* | 873 ± 180† |
| PGE2, pmol | 1.8 ± 0.3 | 11.1 ± 1.3* | 9.5 ± 1.2‡ |
DRGs were collected 60 minutes after intraperitoneal injection of vehicle (ratio of DMSO to Tween 80 to saline, 13.5%:0.5%:86%) or drug. HbAA-BERK mice were injected with vehicle; HbSS-BERK mice were injected with vehicle or R-flurbiprofen (9 mg/kg). Lipids of interest were normalized to the total lipid (grams) within each sample and are expressed as the mean ± SEM. Data were converted to log10 for parametric statistical analysis. n indicates the sample size.
Different from HbAA mice within the same lipid at P < .003.
Different from HbSS mice within the same lipid at P < .001 (1-way ANOVA, Bonferroni t test).
Different at P < .001.