Sensitivity to ATRA and ATO of the 12 fusion genes involving RARA that have been recognized so far, excluding PML-RARA
| RARA rearrangements . | Translocations . | No. of cases reported . | ATRA sensitivity . | ATO sensitivity . | First report Ref. . |
|---|---|---|---|---|---|
| ZBTB16-RARA | t(11;17)(q23;q21) | >30 | Poorly responsive | Poorly responsive | 64 |
| NPM-RARA | t(5;17)(q35;q21) | ? | Sensitive | ND | 65 |
| NuMA-RARA | t(11;17)(q13;q21) | 1 | Sensitive | ND | 66 |
| STAT5b-RARA | der(17) | 9 | Poorly responsive | Poorly responsive | 67 |
| PRKAR1A-RARA | t(17;17)(q21;q24) or del(17)(q21;q24) | 1 | Sensitive | Sensitive | 68 |
| FIP1L1-RARA | t(4;17)(q12;q21) | 2 | Sensitive in 1 case | ND | 69 |
| BCoR-RARA | t(X;17)(p11;q21) | 2 | Sensitive in 2 cases | Insensitive in 1 case | 49 |
| OBFC2A-RARA | t(2;17)(q32;q21) | 1 | Sensitive, in vitro sensitive in 1 of 2 cases | ND | 50 |
| TBLR1-RARA | t(3;17)(q26;q21) | 1 | Insensitive | ND | 51 |
| GTF2I-RARA | t(7;17)(q11;q21) | 1 | Sensitive | Sensitive | 52 |
| IRF2BP2-RARA | t(1;17)(q42;q21) | 3 | Sensitive | Sensitive | 53 |
| FNDC3B-RARA | t(1;17)(q42;q21) | 1 | Sensitive | Sensitive | 54 |
| RARA rearrangements . | Translocations . | No. of cases reported . | ATRA sensitivity . | ATO sensitivity . | First report Ref. . |
|---|---|---|---|---|---|
| ZBTB16-RARA | t(11;17)(q23;q21) | >30 | Poorly responsive | Poorly responsive | 64 |
| NPM-RARA | t(5;17)(q35;q21) | ? | Sensitive | ND | 65 |
| NuMA-RARA | t(11;17)(q13;q21) | 1 | Sensitive | ND | 66 |
| STAT5b-RARA | der(17) | 9 | Poorly responsive | Poorly responsive | 67 |
| PRKAR1A-RARA | t(17;17)(q21;q24) or del(17)(q21;q24) | 1 | Sensitive | Sensitive | 68 |
| FIP1L1-RARA | t(4;17)(q12;q21) | 2 | Sensitive in 1 case | ND | 69 |
| BCoR-RARA | t(X;17)(p11;q21) | 2 | Sensitive in 2 cases | Insensitive in 1 case | 49 |
| OBFC2A-RARA | t(2;17)(q32;q21) | 1 | Sensitive, in vitro sensitive in 1 of 2 cases | ND | 50 |
| TBLR1-RARA | t(3;17)(q26;q21) | 1 | Insensitive | ND | 51 |
| GTF2I-RARA | t(7;17)(q11;q21) | 1 | Sensitive | Sensitive | 52 |
| IRF2BP2-RARA | t(1;17)(q42;q21) | 3 | Sensitive | Sensitive | 53 |
| FNDC3B-RARA | t(1;17)(q42;q21) | 1 | Sensitive | Sensitive | 54 |
ND, not determined; Ref., reference citation number.