Univariable and multivariable analysis for OS
| Parameter . | Univariable analysis (n = 5095) . | Multivariable analysis (n = 2376) . | ||||
|---|---|---|---|---|---|---|
| HR . | 95% CI . | P . | HR . | 95% CI . | P . | |
| Male | 1.202 | 1.070-1.350 | .001 | 1.159 | 0.974-1.379 | .09 |
| Low-CK/intermediate-CK | 1.216 | 1.007-1.470 | .042 | 1.214 | 0.918-1.606 | .17 |
| High-CK | 2.059 | 1.789-2.370 | <.001 | 2.226 | 1.603-3.092 | <.001 |
| idel(13q) | 0.894 | 0.792-1.010 | .07 | — | — | — |
| Trisomy 12 | 1.310 | 1.125-1.525 | <.001 | 1.206 | 0.979-1.487 | .08 |
| del(11q) | 1.942 | 1.659-2.273 | <.001 | 1.152 | 0.914-1.451 | .23 |
| TP53abs | 2.904 | 2.517-3.350 | <.001 | 1.960 | 1.558-2.465 | <.001 |
| U-CLL | 2.851 | 2.467-3.295 | <.001 | 2.320 | 1.927-2.793 | <.001 |
| Binet B/C | 2.036 | 1.793-2.312 | <.001 | 1.575 | 1.313-1.888 | <.001 |
| Parameter . | Univariable analysis (n = 5095) . | Multivariable analysis (n = 2376) . | ||||
|---|---|---|---|---|---|---|
| HR . | 95% CI . | P . | HR . | 95% CI . | P . | |
| Male | 1.202 | 1.070-1.350 | .001 | 1.159 | 0.974-1.379 | .09 |
| Low-CK/intermediate-CK | 1.216 | 1.007-1.470 | .042 | 1.214 | 0.918-1.606 | .17 |
| High-CK | 2.059 | 1.789-2.370 | <.001 | 2.226 | 1.603-3.092 | <.001 |
| idel(13q) | 0.894 | 0.792-1.010 | .07 | — | — | — |
| Trisomy 12 | 1.310 | 1.125-1.525 | <.001 | 1.206 | 0.979-1.487 | .08 |
| del(11q) | 1.942 | 1.659-2.273 | <.001 | 1.152 | 0.914-1.451 | .23 |
| TP53abs | 2.904 | 2.517-3.350 | <.001 | 1.960 | 1.558-2.465 | <.001 |
| U-CLL | 2.851 | 2.467-3.295 | <.001 | 2.320 | 1.927-2.793 | <.001 |
| Binet B/C | 2.036 | 1.793-2.312 | <.001 | 1.575 | 1.313-1.888 | <.001 |
High-CK (≥5 aberrations) is an independent predictor for shorter OS contrasting low-CK/intermediate-CK (3 and 4 aberrations, respectively), which failed to retain significance in the multivariable analysis. Abbreviations are explained in Table 1.