Disulfide bridge connections in VWF C4
| S-S bridge . | Residue (1) . | Secondary structure . | Residue (2) . | Secondary structure . | SD1/SD2 hinge determining . | Comment . |
|---|---|---|---|---|---|---|
| 1 | 2499 | βI′ (SD1) | 2533 | βII (SD1) | No | Intra SD1, canonical |
| 2 | 2528 | Loop βI-βII (SD1) | 2570 | Loop βI-βII (SD2) | Yes | SD1/SD2, canonical |
| 3 | Missing | |||||
| 4 | 2549 | Hinge SD1/SD2 | 2571 | Loop βI-βII (SD2) | Yes | SD1/SD2, canonical |
| 5 | 2557 | 2576 | βII (SD2) | No | SD2, noncanonical | |
| C4 | 2565 | βI (SD2) | 2574 | βII (SD2) | No | C4 only, noncanonical |
| S-S bridge . | Residue (1) . | Secondary structure . | Residue (2) . | Secondary structure . | SD1/SD2 hinge determining . | Comment . |
|---|---|---|---|---|---|---|
| 1 | 2499 | βI′ (SD1) | 2533 | βII (SD1) | No | Intra SD1, canonical |
| 2 | 2528 | Loop βI-βII (SD1) | 2570 | Loop βI-βII (SD2) | Yes | SD1/SD2, canonical |
| 3 | Missing | |||||
| 4 | 2549 | Hinge SD1/SD2 | 2571 | Loop βI-βII (SD2) | Yes | SD1/SD2, canonical |
| 5 | 2557 | 2576 | βII (SD2) | No | SD2, noncanonical | |
| C4 | 2565 | βI (SD2) | 2574 | βII (SD2) | No | C4 only, noncanonical |