Structural statistics of the VWF C4 domain NMR ensemble
| Experimental restraints | |
| Total NOEs | 2478 (assigned 2255) |
| Distance restraints | 1158 |
| Short range (|i − j| ≤ 1) | 650 |
| Medium range (|i − j| < 5) | 85 |
| Long range (|i − j| > 5) | 423 |
| Dihedral restraints (φ/ψ) | 144 |
| Structural quality | |
| Coordinate precision (Å, residues 2496-2503, 2513-2548) | |
| Backbone (N, Cα, C′) | 0.46 ± 0.16 |
| Heavy atoms | 0.77 ± 0.13 |
| Coordinate precision (Å, residues 2562-2577) | |
| Backbone (N, Cα, C′) | 0.39 ± 0.15 |
| Heavy atoms | 1.10 ± 0.20 |
| Restraint RMSD | |
| Distance restraints, Å | 0.018 ± 0.001 |
| Dihedral restraints, ° | 1.45 ± 0.24 |
| Deviation from idealized geometry | |
| Bond lengths, Å | 0.004 ± 0.0002 |
| Bond angles, ° | 0.52 ± 0.02 |
| Ramachandran analysis, % | |
| Favored regions | 84.7 |
| Allowed regions | 14.0 |
| Generously allowed | 0.0 |
| Disallowed | 1.3 |
| Whatcheck analysis | |
| First-generation packing | −3.061 |
| Second-generation packing | −3.531 |
| Ramachandran plot appearance | −3.266 |
| χ−1/χ−2 rotamer normality | −2.452 |
| Backbone conformation | −0.861 |
| Experimental restraints | |
| Total NOEs | 2478 (assigned 2255) |
| Distance restraints | 1158 |
| Short range (|i − j| ≤ 1) | 650 |
| Medium range (|i − j| < 5) | 85 |
| Long range (|i − j| > 5) | 423 |
| Dihedral restraints (φ/ψ) | 144 |
| Structural quality | |
| Coordinate precision (Å, residues 2496-2503, 2513-2548) | |
| Backbone (N, Cα, C′) | 0.46 ± 0.16 |
| Heavy atoms | 0.77 ± 0.13 |
| Coordinate precision (Å, residues 2562-2577) | |
| Backbone (N, Cα, C′) | 0.39 ± 0.15 |
| Heavy atoms | 1.10 ± 0.20 |
| Restraint RMSD | |
| Distance restraints, Å | 0.018 ± 0.001 |
| Dihedral restraints, ° | 1.45 ± 0.24 |
| Deviation from idealized geometry | |
| Bond lengths, Å | 0.004 ± 0.0002 |
| Bond angles, ° | 0.52 ± 0.02 |
| Ramachandran analysis, % | |
| Favored regions | 84.7 |
| Allowed regions | 14.0 |
| Generously allowed | 0.0 |
| Disallowed | 1.3 |
| Whatcheck analysis | |
| First-generation packing | −3.061 |
| Second-generation packing | −3.531 |
| Ramachandran plot appearance | −3.266 |
| χ−1/χ−2 rotamer normality | −2.452 |
| Backbone conformation | −0.861 |