Clinicopathological features of 11 HHV8-negative EBL cases
| ID . | Age, y . | Sex . | Effusion site . | Treatment . | Follow-up, mo . | Vital status . | EBER . | HHV8 . | CD20 . | CD79a . | CD138 . | COO . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 001 | 85 | M | Pericardium | Aspiration | 4 | DOOC | − | − | + | − | − | Non-GCB |
| 002 | 77 | F | Pleural | Aspiration | 14 | Alive, NED | − | − | + | + | − | Non-GCB |
| 003 | 86 | F | Pleural | Aspiration, pleuradesis | 39 | Alive, NED | − | − | + | + | − | Non-GCB |
| 004 | 83 | F | Pleural | R-chlorambucil | 99 | Alive, NED | − | − | + | + | − | Non-GCB |
| 005 | 91 | F | Pleural | Aspiration | 1 | DOOC | − | − | − | − | + | Non-GCB |
| 006 | 75 | F | Pleural | No treatment | 16 | DOOC, NED | − | − | + | + | − | GCB |
| 007 | 92 | M | Pleural | Aspiration | 1 | DOOC | − | − | + | + | − | Non-GCB |
| 008 | 60 | F | Pleural | Aspiration | 4 | Not known | − | − | + | + | − | Non-GCB |
| 009 | 88 | M | Pleural | Aspiration | 1 | DOOC | − | − | + | + | − | Non-GCB |
| 010 | 85 | F | Pleural | Chlorambucil, prednisone | 3 | DOOC | − | − | + | nd | nd | nd |
| 011 | 88 | M | Pleural | No treatment | 7 | DOOC | − | − | + | − | − | Non-GCB |
| ID . | Age, y . | Sex . | Effusion site . | Treatment . | Follow-up, mo . | Vital status . | EBER . | HHV8 . | CD20 . | CD79a . | CD138 . | COO . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 001 | 85 | M | Pericardium | Aspiration | 4 | DOOC | − | − | + | − | − | Non-GCB |
| 002 | 77 | F | Pleural | Aspiration | 14 | Alive, NED | − | − | + | + | − | Non-GCB |
| 003 | 86 | F | Pleural | Aspiration, pleuradesis | 39 | Alive, NED | − | − | + | + | − | Non-GCB |
| 004 | 83 | F | Pleural | R-chlorambucil | 99 | Alive, NED | − | − | + | + | − | Non-GCB |
| 005 | 91 | F | Pleural | Aspiration | 1 | DOOC | − | − | − | − | + | Non-GCB |
| 006 | 75 | F | Pleural | No treatment | 16 | DOOC, NED | − | − | + | + | − | GCB |
| 007 | 92 | M | Pleural | Aspiration | 1 | DOOC | − | − | + | + | − | Non-GCB |
| 008 | 60 | F | Pleural | Aspiration | 4 | Not known | − | − | + | + | − | Non-GCB |
| 009 | 88 | M | Pleural | Aspiration | 1 | DOOC | − | − | + | + | − | Non-GCB |
| 010 | 85 | F | Pleural | Chlorambucil, prednisone | 3 | DOOC | − | − | + | nd | nd | nd |
| 011 | 88 | M | Pleural | No treatment | 7 | DOOC | − | − | + | − | − | Non-GCB |
+, immunohistochemical staining positive; −, immunohistochemical staining negative; COO, cell of origin; DOOC, died of other causes; EBER, EBV-encoded small RNA; F, female; GCB, germinal center B-cell–like; ID, identity; M, male; NED, no evidence of disease.