Mutations in BCR pathway members in pretreatment archival tumor tissue or CSF
| Patient ID . | Disease . | COO/status . | Best response (duration, mo) . | MYD88 . | CD79B . | CARD11 . | MALT1 . | TNFAIP3 . | PLCG2 . |
|---|---|---|---|---|---|---|---|---|---|
| #5 | PCNSL | ABC/recu | CR (24)* | L265P (C) | Y196H (C) | WT (C) | WT (C) | WT (C) | WT (C) |
| #8 | PCNSL | ABC/recu | CR (19.4)* | L265P (C) | Y196H (C) | WT (C) | WT (C) | WT (C) | WT (C) |
| #12 | PCNSL | ABC/recu | CR (16.7)* | WT (C) | Y196H (T) | WT (C) | WT (C) | WT (C) | WT (C) |
| #4 | PCNSL | ABC/recu | CR (9.2) | L265P (T) | X185splice/D185N (T) | F97Y (T) | WT (T) | WT (T) | WT (T) |
| #9 | PCNSL | ABC/recu | CR (4.3)† | WT (C) | WT (C) | WT (C) | WT (C) | WT (C) | WT (C) |
| #7 | PCNSL | ABC/recu | CR (4)† | WT (C) | WT (C) | M166T (C) | WT (C) | WT (C) | WT (C) |
| #13 | PCNSL | ABC/recu | PR (4.3)† | L265P (T) | Y196S (T) | R418K (T) | WT (T) | WT (T) | WT (T) |
| #15 | PCNSL | GCB/recu | PR (3.8)† | L265P (C) | Y196S/D201G (C) | WT (C) | WT (C) | WT (C) | WT (C) |
| #10 | PCNSL | GCB/refr | PD (0.9) | WT (T) | WT (T) | T128M/K252E (T) | WT (T) | WT (T) | WT (T) |
| #14 | SCNSL | GCB/new | CR (13.8)* | L265P (C) | Y196C (C) | WT (C) | WT (C) | WT (C) | WT (C) |
| #6 | SCNSL | ABC/new | PR (4.47) | L265P (T) | WT (T) | WT (T) | AMP (T) | WT (T) | WT (T) |
| #1 | SCNSL | GCB/recu | PR (4)† | D288_F298del (T) | Y196F/M164I (T) | K215M (T) | WT (T) | C483W (T) | WT (T) |
| #11 | SCNSL | GCB/new | PR (3.4) | A272P (C) | WT (C) | S66A/L251P/R418S (C) | WT (C) | WT (C) | WT (C) |
| #2 | SCNSL | GCB/refr | SD (1.5) | WT (T) | WT (T) | WT (T) | WT (T) | WT (T) | R268W (T) |
| #3 | SCNSL | GCB/refr | PD (0.9) | WT (C) | WT (C) | WT (C) | WT (C) | WT (C) | WT (C) |
| Patient ID . | Disease . | COO/status . | Best response (duration, mo) . | MYD88 . | CD79B . | CARD11 . | MALT1 . | TNFAIP3 . | PLCG2 . |
|---|---|---|---|---|---|---|---|---|---|
| #5 | PCNSL | ABC/recu | CR (24)* | L265P (C) | Y196H (C) | WT (C) | WT (C) | WT (C) | WT (C) |
| #8 | PCNSL | ABC/recu | CR (19.4)* | L265P (C) | Y196H (C) | WT (C) | WT (C) | WT (C) | WT (C) |
| #12 | PCNSL | ABC/recu | CR (16.7)* | WT (C) | Y196H (T) | WT (C) | WT (C) | WT (C) | WT (C) |
| #4 | PCNSL | ABC/recu | CR (9.2) | L265P (T) | X185splice/D185N (T) | F97Y (T) | WT (T) | WT (T) | WT (T) |
| #9 | PCNSL | ABC/recu | CR (4.3)† | WT (C) | WT (C) | WT (C) | WT (C) | WT (C) | WT (C) |
| #7 | PCNSL | ABC/recu | CR (4)† | WT (C) | WT (C) | M166T (C) | WT (C) | WT (C) | WT (C) |
| #13 | PCNSL | ABC/recu | PR (4.3)† | L265P (T) | Y196S (T) | R418K (T) | WT (T) | WT (T) | WT (T) |
| #15 | PCNSL | GCB/recu | PR (3.8)† | L265P (C) | Y196S/D201G (C) | WT (C) | WT (C) | WT (C) | WT (C) |
| #10 | PCNSL | GCB/refr | PD (0.9) | WT (T) | WT (T) | T128M/K252E (T) | WT (T) | WT (T) | WT (T) |
| #14 | SCNSL | GCB/new | CR (13.8)* | L265P (C) | Y196C (C) | WT (C) | WT (C) | WT (C) | WT (C) |
| #6 | SCNSL | ABC/new | PR (4.47) | L265P (T) | WT (T) | WT (T) | AMP (T) | WT (T) | WT (T) |
| #1 | SCNSL | GCB/recu | PR (4)† | D288_F298del (T) | Y196F/M164I (T) | K215M (T) | WT (T) | C483W (T) | WT (T) |
| #11 | SCNSL | GCB/new | PR (3.4) | A272P (C) | WT (C) | S66A/L251P/R418S (C) | WT (C) | WT (C) | WT (C) |
| #2 | SCNSL | GCB/refr | SD (1.5) | WT (T) | WT (T) | WT (T) | WT (T) | WT (T) | R268W (T) |
| #3 | SCNSL | GCB/refr | PD (0.9) | WT (C) | WT (C) | WT (C) | WT (C) | WT (C) | WT (C) |