Adverse events, most common events (>10% of patients), and all grade 3 or 4 toxicities
| Adverse event . | Grade 1 or 2 . | Grade 3 . | Grade 4 . | Total . |
|---|---|---|---|---|
| Anemia | 12 (80) | 3 (20) | — | 15 (100) |
| Aspartate aminotransferase increased | 10 (67) | 5 (33) | — | 13 (87) |
| Platelet count decreased | 11 (73) | 1 (7) | — | 12 (80) |
| Alanine aminotransferase increased | 11 (73) | 1 (7) | — | 12 (80) |
| Lymphocyte count decreased | — | 8 (53) | 1 (7) | 9 (60) |
| White blood cell decreased | 8 (53) | 1 (7) | — | 9 (60) |
| Hyperglycemia | 7 (47) | 1 (7) | — | 8 (53) |
| Neutrophil count decreased | 4 (27) | 1 (7) | 1 (7) | 6 (40) |
| Alkaline phosphatase increased | 7 (47) | — | — | 7 (47) |
| Blood bilirubin increased | 7 (47) | — | — | 7 (47) |
| Cholesterol high | 7 (47) | — | — | 7 (47) |
| Hypokalemia | 6 (40) | 1 (7) | — | 7 (47) |
| Hypocalcemia | 4 (27) | 1 (7) | — | 5 (33) |
| Fatigue | 5 (33) | — | — | 5 (33) |
| Creatinine increased | 4 (27) | — | — | 4 (27) |
| Nausea | 4 (27) | — | — | 4 (27) |
| Musculoskeletal and connective tissue disorder (cramps) | 4 (27) | — | — | 4 (27) |
| Lung infection | — | 2 (13) | 1 (7) | 3 (20) |
| Hyponatremia | 2 (13) | 1 (7) | — | 3 (20) |
| Activated partial thromboplastin time prolonged | 3 (20) | — | — | 3 (20) |
| Hypertriglyceridemia | 3 (20) | — | — | 3 (20) |
| Hypoalbuminemia | 3 (20) | — | — | 3 (20) |
| Diarrhea | 1 (7) | 1 (7) | — | 2 (13) |
| Acute kidney injury | 2 (13) | — | — | 2 (13) |
| Arthralgia | 2 (13) | — | — | 2 (13) |
| Headache | 2 (13) | — | — | 2 (13) |
| Infections and infestations - other (infection of unknown origin) | — | 1 (7) | — | 1 (7) |
| Hyperkalemia | — | 1 (7) | — | 1 (7) |
| Adverse event . | Grade 1 or 2 . | Grade 3 . | Grade 4 . | Total . |
|---|---|---|---|---|
| Anemia | 12 (80) | 3 (20) | — | 15 (100) |
| Aspartate aminotransferase increased | 10 (67) | 5 (33) | — | 13 (87) |
| Platelet count decreased | 11 (73) | 1 (7) | — | 12 (80) |
| Alanine aminotransferase increased | 11 (73) | 1 (7) | — | 12 (80) |
| Lymphocyte count decreased | — | 8 (53) | 1 (7) | 9 (60) |
| White blood cell decreased | 8 (53) | 1 (7) | — | 9 (60) |
| Hyperglycemia | 7 (47) | 1 (7) | — | 8 (53) |
| Neutrophil count decreased | 4 (27) | 1 (7) | 1 (7) | 6 (40) |
| Alkaline phosphatase increased | 7 (47) | — | — | 7 (47) |
| Blood bilirubin increased | 7 (47) | — | — | 7 (47) |
| Cholesterol high | 7 (47) | — | — | 7 (47) |
| Hypokalemia | 6 (40) | 1 (7) | — | 7 (47) |
| Hypocalcemia | 4 (27) | 1 (7) | — | 5 (33) |
| Fatigue | 5 (33) | — | — | 5 (33) |
| Creatinine increased | 4 (27) | — | — | 4 (27) |
| Nausea | 4 (27) | — | — | 4 (27) |
| Musculoskeletal and connective tissue disorder (cramps) | 4 (27) | — | — | 4 (27) |
| Lung infection | — | 2 (13) | 1 (7) | 3 (20) |
| Hyponatremia | 2 (13) | 1 (7) | — | 3 (20) |
| Activated partial thromboplastin time prolonged | 3 (20) | — | — | 3 (20) |
| Hypertriglyceridemia | 3 (20) | — | — | 3 (20) |
| Hypoalbuminemia | 3 (20) | — | — | 3 (20) |
| Diarrhea | 1 (7) | 1 (7) | — | 2 (13) |
| Acute kidney injury | 2 (13) | — | — | 2 (13) |
| Arthralgia | 2 (13) | — | — | 2 (13) |
| Headache | 2 (13) | — | — | 2 (13) |
| Infections and infestations - other (infection of unknown origin) | — | 1 (7) | — | 1 (7) |
| Hyperkalemia | — | 1 (7) | — | 1 (7) |
All data are shown as number of patients (%).
—, not observed.