Patient demographic and baseline disease characteristics
| . | N (%) . | |||||
|---|---|---|---|---|---|---|
| CrCL, mL/min . | ||||||
| ≥15 to <50 . | 50 to <80 . | ≥80 . | ||||
| Kd56 (n = 85) . | Vd (n = 99) . | Kd56 (n = 186) . | Vd (n = 177) . | Kd56 (n = 193) . | Vd (n = 189) . | |
| Age, y | ||||||
| Median | 72.0 | 72.0 | 68.0 | 68.0 | 60.0 | 61.0 |
| Range | 41-89 | 45-86 | 39-89 | 44-88 | 35-81 | 30-81 |
| <65 | 22 (25.9) | 22 (22.2) | 64 (34.4) | 53 (29.9) | 137 (71.0) | 135 (71.4) |
| 65-74 | 28 (32.9) | 44 (44.4) | 85 (45.7) | 97 (54.8) | 51 (26.4) | 48 (25.4) |
| ≥75 | 35 (41.2) | 33 (33.3) | 37 (19.9) | 27 (15.3) | 5 (2.6) | 6 (3.2) |
| Sex | ||||||
| Female | 45 (52.9) | 62 (62.6) | 96 (51.6) | 105 (59.3) | 83 (43.0) | 69 (36.5) |
| Male | 40 (47.1) | 37 (37.4) | 90 (48.4) | 72 (40.7) | 110 (57.0) | 120 (63.5) |
| Race | ||||||
| White | 54 (63.5) | 75 (75.8) | 143 (76.9) | 133 (75.1) | 156 (80.8) | 153 (81.0) |
| Black | 1 (1.2) | 0 | 3 (1.6) | 5 (2.8) | 3 (1.6) | 4 (2.1) |
| Asian | 18 (21.2) | 16 (16.2) | 20 (10.8) | 19 (10.7) | 18 (9.3) | 22 (11.6) |
| Not reported | 12 (14.1) | 8 (8.1) | 20 (10.8) | 20 (11.3) | 14 (7.3) | 9 (4.8) |
| Other | 0 | 0 | 0 | 0 | 2 (1.0) | 1 (0.5) |
| Cytogenetic risk by FISH at study entry* | ||||||
| High | 11 (12.9) | 26 (26.3) | 45 (24.2) | 41 (23.2) | 41 (21.2) | 46 (24.3) |
| Standard | 55 (64.7) | 61 (61.6) | 111 (59.7) | 117 (66.1) | 118 (61.1) | 113 (59.8) |
| Unknown/missing | 19 (22.4) | 12 (12.1) | 30 (16.1) | 19 (10.7) | 34 (17.6) | 30 (15.9) |
| ISS stage at baseline | ||||||
| 1 | 11 (12.9) | 9 (9.1) | 76 (40.9) | 69 (39.0) | 125 (64.8) | 127 (67.2) |
| 2 | 28 (32.9) | 28 (28.3) | 66 (35.5) | 75 (42.4) | 45 (23.3) | 48 (25.4) |
| 3 | 46 (54.1) | 62 (62.6) | 44 (23.7) | 33 (18.6) | 23 (11.9) | 14 (7.4) |
| N of prior regimens | ||||||
| 1 | 39 (45.9) | 43 (43.4) | 96 (51.6) | 85 (48.0) | 96 (49.7) | 101 (53.4) |
| 2-3 | 46 (54.1) | 56 (56.6) | 90 (48.4) | 92 (52.0) | 97 (50.3) | 88 (46.6) |
| . | N (%) . | |||||
|---|---|---|---|---|---|---|
| CrCL, mL/min . | ||||||
| ≥15 to <50 . | 50 to <80 . | ≥80 . | ||||
| Kd56 (n = 85) . | Vd (n = 99) . | Kd56 (n = 186) . | Vd (n = 177) . | Kd56 (n = 193) . | Vd (n = 189) . | |
| Age, y | ||||||
| Median | 72.0 | 72.0 | 68.0 | 68.0 | 60.0 | 61.0 |
| Range | 41-89 | 45-86 | 39-89 | 44-88 | 35-81 | 30-81 |
| <65 | 22 (25.9) | 22 (22.2) | 64 (34.4) | 53 (29.9) | 137 (71.0) | 135 (71.4) |
| 65-74 | 28 (32.9) | 44 (44.4) | 85 (45.7) | 97 (54.8) | 51 (26.4) | 48 (25.4) |
| ≥75 | 35 (41.2) | 33 (33.3) | 37 (19.9) | 27 (15.3) | 5 (2.6) | 6 (3.2) |
| Sex | ||||||
| Female | 45 (52.9) | 62 (62.6) | 96 (51.6) | 105 (59.3) | 83 (43.0) | 69 (36.5) |
| Male | 40 (47.1) | 37 (37.4) | 90 (48.4) | 72 (40.7) | 110 (57.0) | 120 (63.5) |
| Race | ||||||
| White | 54 (63.5) | 75 (75.8) | 143 (76.9) | 133 (75.1) | 156 (80.8) | 153 (81.0) |
| Black | 1 (1.2) | 0 | 3 (1.6) | 5 (2.8) | 3 (1.6) | 4 (2.1) |
| Asian | 18 (21.2) | 16 (16.2) | 20 (10.8) | 19 (10.7) | 18 (9.3) | 22 (11.6) |
| Not reported | 12 (14.1) | 8 (8.1) | 20 (10.8) | 20 (11.3) | 14 (7.3) | 9 (4.8) |
| Other | 0 | 0 | 0 | 0 | 2 (1.0) | 1 (0.5) |
| Cytogenetic risk by FISH at study entry* | ||||||
| High | 11 (12.9) | 26 (26.3) | 45 (24.2) | 41 (23.2) | 41 (21.2) | 46 (24.3) |
| Standard | 55 (64.7) | 61 (61.6) | 111 (59.7) | 117 (66.1) | 118 (61.1) | 113 (59.8) |
| Unknown/missing | 19 (22.4) | 12 (12.1) | 30 (16.1) | 19 (10.7) | 34 (17.6) | 30 (15.9) |
| ISS stage at baseline | ||||||
| 1 | 11 (12.9) | 9 (9.1) | 76 (40.9) | 69 (39.0) | 125 (64.8) | 127 (67.2) |
| 2 | 28 (32.9) | 28 (28.3) | 66 (35.5) | 75 (42.4) | 45 (23.3) | 48 (25.4) |
| 3 | 46 (54.1) | 62 (62.6) | 44 (23.7) | 33 (18.6) | 23 (11.9) | 14 (7.4) |
| N of prior regimens | ||||||
| 1 | 39 (45.9) | 43 (43.4) | 96 (51.6) | 85 (48.0) | 96 (49.7) | 101 (53.4) |
| 2-3 | 46 (54.1) | 56 (56.6) | 90 (48.4) | 92 (52.0) | 97 (50.3) | 88 (46.6) |
FISH, fluorescence in situ hybridization.
High-risk patients have genetic subtype t(4; 14), t(14;16), or del(17p); standard-risk patients do not. The unknown risk group includes patients who have FISH assessment, but the results for ≥1 genetic subtype are not available.