Phenotype of mice with double vs single knockout of key players in liver iron sensing
| Double mutant . | Compared with . | Hamp levels . | Liver iron . | Extrahepatic iron loading . | Anemia . | References . |
|---|---|---|---|---|---|---|
| Bmp6 × Hjv | Bmp6 or Hjv | (F) ↓↓↓ (M) ↓↓ | → | (F) ↑↑ (M) → | No | 90,107 |
| Bmp6 × β2m | β2m | ↓↓↓ | ↑↑ | ↑↑ | No | 107 |
| Bmp6 | (F) ↓↓↓ (M) ↓↓ | → | (F) ↑↑ (M) → | |||
| Bmp6 × Tfr2 | Tfr2 | ↓↓↓ | ↑ | ↑↑ | 107 | |
| Bmp6 | (F) ↓↓↓ (M) ↓↓ | → | (F) ↑ (M) → | |||
| Hjv × Hfe | Hfe | ↓↓ | ↑↑↑ | n/a | No | 10,106 |
| Hjv | → | → | n/a | |||
| Hjv × Tfr2 | Tfr2 | → | ↑ | n/a | No | 105,106 |
| Hjv | → | → | n/a | |||
| Hfe × Tfr2 | Hfe | ↓↓ | ↑↑ | n/a | No | 97 |
| Tfr2 | ↓ | ↑ | n/a | |||
| Acvr2a × Bmpr2* | Acvr2a* or Bmpr2* | ↓↓↓ | ↑↑↑↑ | n/a | No | 69 |
| Smad1 × Smad5* | Smad1* or Smad5* | ↓↓↓ | ↑↑↑↑ | n/a | No | 70 |
| Tmprss6 × Hfe | Tmprss6 | → | → | → | Yes | 116 |
| Hfe | ↑ | ↓ | ↓ | |||
| Tmprss6 × Hjv | Tmprss6 | ↓↓↓ | ↑↑↑↑ | ↑↑ | No | 109 |
| Hjv | → | → | → | |||
| Tmprss6 × Tfr2 | Tmprss6 | → | → | n/a | Yes | 109,117 |
| Tmprss6 × Bmp6 | Tmprss6 | ↓ | ↑ | → | No | 149 |
| Bmp6 | ↑↑ | ↓↓ | ↓ |
| Double mutant . | Compared with . | Hamp levels . | Liver iron . | Extrahepatic iron loading . | Anemia . | References . |
|---|---|---|---|---|---|---|
| Bmp6 × Hjv | Bmp6 or Hjv | (F) ↓↓↓ (M) ↓↓ | → | (F) ↑↑ (M) → | No | 90,107 |
| Bmp6 × β2m | β2m | ↓↓↓ | ↑↑ | ↑↑ | No | 107 |
| Bmp6 | (F) ↓↓↓ (M) ↓↓ | → | (F) ↑↑ (M) → | |||
| Bmp6 × Tfr2 | Tfr2 | ↓↓↓ | ↑ | ↑↑ | 107 | |
| Bmp6 | (F) ↓↓↓ (M) ↓↓ | → | (F) ↑ (M) → | |||
| Hjv × Hfe | Hfe | ↓↓ | ↑↑↑ | n/a | No | 10,106 |
| Hjv | → | → | n/a | |||
| Hjv × Tfr2 | Tfr2 | → | ↑ | n/a | No | 105,106 |
| Hjv | → | → | n/a | |||
| Hfe × Tfr2 | Hfe | ↓↓ | ↑↑ | n/a | No | 97 |
| Tfr2 | ↓ | ↑ | n/a | |||
| Acvr2a × Bmpr2* | Acvr2a* or Bmpr2* | ↓↓↓ | ↑↑↑↑ | n/a | No | 69 |
| Smad1 × Smad5* | Smad1* or Smad5* | ↓↓↓ | ↑↑↑↑ | n/a | No | 70 |
| Tmprss6 × Hfe | Tmprss6 | → | → | → | Yes | 116 |
| Hfe | ↑ | ↓ | ↓ | |||
| Tmprss6 × Hjv | Tmprss6 | ↓↓↓ | ↑↑↑↑ | ↑↑ | No | 109 |
| Hjv | → | → | → | |||
| Tmprss6 × Tfr2 | Tmprss6 | → | → | n/a | Yes | 109,117 |
| Tmprss6 × Bmp6 | Tmprss6 | ↓ | ↑ | → | No | 149 |
| Bmp6 | ↑↑ | ↓↓ | ↓ |
Levels of hepcidin expression and tissue iron loading are subject to variation based on background strains ages, and analytical variations in different studies.
Hepatocyte conditional knockout.