Definition of terms in 2019 ASH guideline on ITP
| Terms and definitions . |
|---|
| Corticosteroid-dependent: Ongoing need for continuous prednisone >5 mg/d (or corticosteroid equivalent) or frequent courses of corticosteroids to maintain a platelet count ≥30 × 109/L and/or to avoid bleeding |
| Durable response: Platelet count ≥30 × 109/L and at least doubling of the baseline count at 6 mo |
| Early response: Platelet count ≥30 × 109/L and at least doubling baseline at 1 wk |
| Initial response: Platelet count ≥30 × 109/L and at least doubling baseline at 1 mo |
| Major bleeding: (1) WHO grade 3 or 4 bleeding, (2) Buchanan severe grade, (3) Bolton-Maggs and Moon “major bleeding,” (4) IBLS grade 2 or higher, or (5) life-threatening or intracerebral hemorrhage bleeding |
| Minor bleeding: Any bleeding not meeting the criteria for “major bleeding” |
| Newly diagnosed ITP: ITP duration of <3 mo |
| Persistent ITP: ITP duration of 3-12 mo |
| Chronic ITP: ITP duration of >12 mo |
| Remission: Platelet count >100 × 109/L at 12 mo |
| Terms and definitions . |
|---|
| Corticosteroid-dependent: Ongoing need for continuous prednisone >5 mg/d (or corticosteroid equivalent) or frequent courses of corticosteroids to maintain a platelet count ≥30 × 109/L and/or to avoid bleeding |
| Durable response: Platelet count ≥30 × 109/L and at least doubling of the baseline count at 6 mo |
| Early response: Platelet count ≥30 × 109/L and at least doubling baseline at 1 wk |
| Initial response: Platelet count ≥30 × 109/L and at least doubling baseline at 1 mo |
| Major bleeding: (1) WHO grade 3 or 4 bleeding, (2) Buchanan severe grade, (3) Bolton-Maggs and Moon “major bleeding,” (4) IBLS grade 2 or higher, or (5) life-threatening or intracerebral hemorrhage bleeding |
| Minor bleeding: Any bleeding not meeting the criteria for “major bleeding” |
| Newly diagnosed ITP: ITP duration of <3 mo |
| Persistent ITP: ITP duration of 3-12 mo |
| Chronic ITP: ITP duration of >12 mo |
| Remission: Platelet count >100 × 109/L at 12 mo |
IBLS, ITP Bleeding Scale; WHO, World Health Organization.