List of the 35 most frequent BCR-ABL1 kinase domain mutations associated with resistance to TKIs (based on the integration of in vitro IC50 data and in vivo observations)
| Mutation . | TKI(s) to which the mutation confers resistance . |
|---|---|
| M244V | Imatinib |
| L248V | Imatinib |
| G250E | Imatinib |
| Q252H | Imatinib |
| Y253H | Imatinib, nilotinib |
| E255V | Imatinib, nilotinib, bosutinib |
| E255K | Imatinib, nilotinib, bosutinib |
| L273M | Imatinib |
| D276G | Imatinib |
| T277A | Imatinib |
| E279K | Imatinib |
| V299L | Dasatinib, bosutinib |
| F311L | Imatinib |
| T315I | Imatinib, nilotinib, dasatinib, bosutinib |
| T315A | Dasatinib |
| T315M | Ponatinib |
| T315L | Ponatinib |
| F317L | Imatinib, dasatinib |
| F317V | Imatinib, dasatinib |
| F317I | Imatinib, dasatinib |
| F317C | Imatinib, dasatinib |
| M351T | Imatinib |
| E355G | Imatinib |
| F359C | Imatinib, nilotinib |
| F359I | Imatinib, nilotinib |
| F359V | Imatinib, nilotinib |
| E379K | Imatinib |
| L384M | Imatinib |
| L387M | Imatinib |
| L387F | Imatinib |
| H396R | Imatinib |
| H396P | Imatinib |
| E459K | Imatinib |
| F486S | Imatinib |
| Mutation . | TKI(s) to which the mutation confers resistance . |
|---|---|
| M244V | Imatinib |
| L248V | Imatinib |
| G250E | Imatinib |
| Q252H | Imatinib |
| Y253H | Imatinib, nilotinib |
| E255V | Imatinib, nilotinib, bosutinib |
| E255K | Imatinib, nilotinib, bosutinib |
| L273M | Imatinib |
| D276G | Imatinib |
| T277A | Imatinib |
| E279K | Imatinib |
| V299L | Dasatinib, bosutinib |
| F311L | Imatinib |
| T315I | Imatinib, nilotinib, dasatinib, bosutinib |
| T315A | Dasatinib |
| T315M | Ponatinib |
| T315L | Ponatinib |
| F317L | Imatinib, dasatinib |
| F317V | Imatinib, dasatinib |
| F317I | Imatinib, dasatinib |
| F317C | Imatinib, dasatinib |
| M351T | Imatinib |
| E355G | Imatinib |
| F359C | Imatinib, nilotinib |
| F359I | Imatinib, nilotinib |
| F359V | Imatinib, nilotinib |
| E379K | Imatinib |
| L384M | Imatinib |
| L387M | Imatinib |
| L387F | Imatinib |
| H396R | Imatinib |
| H396P | Imatinib |
| E459K | Imatinib |
| F486S | Imatinib |